Plummer-Vinson syndrome (PVS) presents with the classic triad of iron-deficiency anemia, dysphagia, and esophageal webs. The mainstay treatment of PVS is iron supplementation and the dysphagia usually responds to iron supplementation before the hematologic abnormalities are corrected. This syndrome classically affects middle-aged Caucasian women and very few cases have been reported in African Americans. We present a rare case of PVS in an African-American woman. A 63-year-old woman presented with shortness of breath, dysphagia, and lightheadedness for several weeks. Chest X-ray was negative for any acute abnormalities. Initial hemoglobin was 7.0 g/dL, which improved to 7.5 g/dL after 1 unit of packed red blood cells. She had a mean corpuscular volume of 62 fL, a ferritin level of 6 ng/mL, and an iron level of 12 μg/dL. Fecal occult blood test was negative and barium swallow revealed a proximal esophageal web. Her dysphagia did not significantly improve despite intravenous iron supplementation and esophageal web dilation. Video-fluoroscopic swallow study revealed esophageal and pharyngeal phase dysphagia with food entrapment. She was discharged with plans to follow up with a primary care physician and repeat esophagogastroduodenoscopy in 1 year. This case report highlights a rare case of PVS in an African-American woman and emphasizes the importance of maintaining a comprehensive and broad differential diagnosis.
Case Rep Gastroenterol 2021;15:557–561

中文翻译：

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非裔美国女性的普卢默-文森综合症

普卢默-文森综合征 (PVS) 表现为典型的缺铁性贫血、吞咽困难和食管蹼三联征。PVS 的主要治疗方法是补充铁剂，在血液学异常得到纠正之前，吞咽困难通常对补充铁剂有反应。这种综合征通常影响中年白人女性，非洲裔美国人中很少有病例报道。我们介绍了一名非裔美国女性患有 PVS 的罕见病例。一名 63 岁女性出现呼吸短促、吞咽困难和头晕数周的症状。胸部 X 光检查未发现任何急性异常。初始血红蛋白为 7.0 g/dL，浓缩红细胞 1 单位后改善至 7.5 g/dL。她的平均红细胞体积为 62 fL，铁蛋白水平为 6 ng/mL，铁水平为 12 μg/dL。粪便隐血试验呈阴性，吞咽钡剂显示近端食管蹼。尽管静脉补充铁剂和食管蹼扩张，但她的吞咽困难并未明显改善。视频透视吞咽研究显示食管和咽期吞咽困难伴有食物滞留。她出院后计划与初级保健医生进行随访，并在一年内再次进行食管胃十二指肠镜检查。本病例报告重点介绍了非裔美国女性的罕见 PVS 病例，并强调了保持全面、广泛鉴别诊断的重要性。
胃肠病病例代表 2021 年；15:557–561