Cardiac diseases are emerging due to lifestyle, urbanization, and the accelerated aging process. Oxidative stress has been associated with cardiac injury progression through interference with antioxidant strategies and endoplasmic reticulum (ER) function. Hydrogen sulfide (H₂S) is generated endogenously from l-cysteine in various tissues including heart tissue. Pharmacological evaluation of H₂S has suggested a potential role for H₂S against diabetic cardiomyopathy, ischemia/reperfusion injury, myocardial infarction, and cardiotoxicity. Nuclear factor E2-related factor 2 (Nrf2) activity is crucial for cell survival in response to oxidative stress. H₂S up-regulates Nrf2 expression and its related signaling pathway in myocytes. H₂S also suppresses the expression and activity of ER stress-related proteins. H₂S has been reported to improve various cardiac conditions through antioxidant and anti-ER stress-related activities.

中文翻译：

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硫化氢靶向内质网应激和 Nrf2 信号通路的心脏保护作用：综述

由于生活方式、城市化和加速老龄化进程，心脏病正在出现。氧化应激通过干扰抗氧化策略和内质网 (ER) 功能与心脏损伤进展有关。硫化氢 (H ₂ S)在包括心脏组织在内的各种组织中由l-半胱氨酸内源性产生。_{H 2} S的药理学评价表明 H ₂ S 对糖尿病性心肌病、缺血/再灌注损伤、心肌梗塞和心脏毒性具有潜在作用。核因子 E2 相关因子 2 (Nrf2) 活性对于响应氧化应激的细胞存活至关重要。H ₂S 上调肌细胞中 Nrf2 的表达及其相关信号通路。H ₂ S 还抑制内质网应激相关蛋白的表达和活性。据报道， H ₂ S 通过抗氧化和抗 ER 应激相关活动改善各种心脏状况。