Abstract

There is a need to find alternative solvents for electrospinning that are less hazardous and more environmentally safe than the Class II solvents currently used. We characterized poly(lactic-co-glycolic acid) (PLGA) nanofibers (NFs) electrospun using a new, less toxic solvent system comprised the Class III solvents acetone:ethyl acetate (ACE:EtAc). Both solvent systems produced amorphous NFs. Fourier-transform infrared spectroscopy (FTIR) showed no change in PLGA composition after electrospinning. ACE:EtAc NFs showed a 53% burst release of paracetamol, followed by a gradual release not statistically different to release from DCM:DMF. ACE:EtAc can be used as a solvent to electrospin PLGA NFs however, with larger fiber diameter.

摘要

需要找到用于静电纺丝的替代溶剂，它们比目前使用的 II 类溶剂危害更小且对环境更安全。我们使用一种新的、毒性较低的溶剂系统对聚（乳酸-乙醇酸）（PLGA）纳米纤维（NFs）进行了表征，该溶剂系统包括 III 类溶剂丙酮：乙酸乙酯（ACE：EtAc）。两种溶剂系统都产生了无定形的 NF。傅里叶变换红外光谱 (FTIR) 显示静电纺丝后 PLGA 组成没有变化。ACE:EtAc NFs 显示出 53% 的扑热息痛释放，随后逐渐释放，与 DCM:DMF 的释放没有统计学差异。ACE:EtAc 可用作静电纺丝 PLGA NFs 的溶剂，但纤维直径较大。