The emphasis of biocompatible polymer applications in medical sciences and biotechnology has remarkably increased. Developing new low-cost, low-toxicity and lightweight composite forms of biopolymers has become even more attractive since the addition of new species into polymer matrices assist to improve biomedical activities of such materials to a higher extend. Developments in nanoscience and nanotechnology recently contribute to controlled fabrication and ultraprecise diagnosis of such materials. This study concerns the observation of solution processing effects in the fabrication of porous PLA/AGNWs bionanocomposite coatings using electron and ion processing based serial cross-sectioning and high-resolution imaging. The nanostructuring and characterization were both performed in a focused ion-beam-scanning electron microscope (FIB-SEM) platform. HR-SEM imaging was conducted on-site to track solvent based morphological property alterations of PLA and PLA/AgNWs structures. Simultaneous SEM-EDS analyses revealed the elemental distribution and the chemical composition along the cross-sectioned regions of the samples. Accordingly, it was observed that, in case of acetone dissolved materials, both pristine PLA and PLA/AgNWs samples sustained their foamy structure. When chloroform was used as the solvent, the porosity of the polymer matrices was less and the resulting structure was found to be denser than samples dissolved in acetone with a lower surface area ratio inside the material. This can be attributed to the rapid volatilization of acetone compared to chloroform, and hence the formation of interconnected pore network. For both nanocomposite biopolymers dissolved in acetone and chloroform, silver nanowires were homogeneously distributed throughout PLA matrices.

生物相容性聚合物在医学科学和生物技术中的应用重点显着增加。开发新的低成本、低毒性和轻质的生物聚合物复合形式变得更具吸引力，因为将新物种添加到聚合物基质中有助于在更高程度上提高此类材料的生物医学活性。最近纳米科学和纳米技术的发展有助于此类材料的受控制造和超精密诊断。本研究涉及使用基于电子和离子处理的串行横截面和高分辨率成像制备多孔 PLA/AGNWs 生物纳米复合涂层中的溶液处理效果的观察。纳米结构和表征均在聚焦离子束扫描电子显微镜 (FIB-SEM) 平台上进行。HR-SEM 成像是在现场进行的，以跟踪 PLA 和 PLA/AgNWs 结构的基于溶剂的形态特性变化。同时 SEM-EDS 分析揭示了沿样品横截面区域的元素分布和化学成分。因此，观察到，在丙酮溶解材料的情况下，原始 PLA 和 PLA/AgNW 样品均保持其泡沫结构。当使用氯仿作为溶剂时，聚合物基质的孔隙率较小，并且发现所得结构比溶解在丙酮中的样品更致密，材料内部的表面积比较低。这可归因于与氯仿相比丙酮的快速挥发，从而形成相互连接的孔隙网络。对于溶解在丙酮和氯仿中的两种纳米复合生物聚合物，银纳米线均匀分布在整个 PLA 基质中。