Background and objective

The clinical outcome and angiographic outcome data of Woven EndoBridge (WEB) device for the treatment of ruptured intracranial aneurysms (IAs) are limited. We conducted a meta-analysis of the latest literature on the WEB device in the treatment of ruptured IAs.

Methods

A comprehensive literature search of 4 databases (PubMed, Web of Science, Cochrane library, and Embase) was conducted for studies published from January 1, 2010 to December 31, 2020. Two reviewers independently extracted variables (aneurysm and patient characteristics) using a prespecified data-collection sheet. Outcomes studied included initial and latest follow-up angiographic outcomes, technical success rate, perioperative mortality, retreated rate, perioperative re-bleeding, complication, intraoperative rupture, favorable neurologic outcome at discharge. We used random-effects model to pool the data.

Results

We finally presented the results of 7 articles including 276 patients with 283 aneurysms. Initial complete and adequate occlusion rate were 38% (95% CI, 25%–50%) and 98% (95% CI, 95%–100%), respectively. Latest follow-up complete and adequate occlusion rate were 61% (95% CI, 46%–75%) and 91% (95% CI, 84%–98%), respectively.Technical success rate was 99% (95% CI, 98%–100%). Perioperative mortality rates and perioperative re-bleeding rate were 9% (95% CI, 3%–15%) and 1% (95% CI, 0%–2%), respectively. Retreated rate was 6% (95% CI, 3%–10%). Overall and WEB treatment-related thromboembolic complication was 10% (95% CI, 6%–13%) and 7% (95% CI, 2%–12%), respectively. Intraoperative rupture rate was 3% (95% CI, 0%–6%).

Conclusion

Endovascular treatment of ruptured IAs with the WEB device has a good safety profile and an acceptable aneurysm occlusion rate.

中文翻译：

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用于治疗颅内动脉瘤破裂的编织 EndoBridge 装置：临床和血管造影结果的系统评价

背景和目标

Woven EndoBridge (WEB) 装置治疗破裂的颅内动脉瘤 (IAs) 的临床结果和血管造影结果数据有限。我们对有关 WEB 装置治疗破裂 IA 的最新文献进行了荟萃分析。

方法

针对 2010 年 1 月 1 日至 2020 年 12 月 31 日发表的研究，对 4 个数据库（PubMed、Web of Science、Cochrane 图书馆和 Embase）进行了全面的文献检索。两位评价者使用预先指定的方法独立提取变量（动脉瘤和患者特征）数据收集表。研究的结果包括初始和最新的随访血管造影结果、技术成功率、围手术期死亡率、再治疗率、围手术期再出血、并发症、术中破裂、出院时良好的神经系统结果。我们使用随机效应模型来汇集数据。

结果

我们最终展示了 7 篇文章的结果，包括 276 名患者和 283 个动脉瘤。初始完全和充分闭塞率分别为 38%（95% CI，25%–50%）和 98%（95% CI，95%–100%）。最新随访完全和充分封堵率分别为 61%（95% CI，46%–75%）和 91%（95% CI，84%–98%）。技术成功率为 99%（95% CI , 98%–100%)。围手术期死亡率和围手术期再出血率分别为 9%（95% CI，3%–15%）和 1%（95% CI，0%–2%）。撤退率为 6%（95% CI，3%–10%）。总体和 WEB 治疗相关的血栓栓塞并发症分别为 10%（95% CI，6%–13%）和 7%（95% CI，2%–12%）。术中破裂率为 3%（95% CI，0%–6%）。

结论

使用 WEB 装置对破裂的 IA 进行血管内治疗具有良好的安全性和可接受的动脉瘤闭塞率。