Terahertz (THz) metamaterials are widely used in biosensor devices due to their unique superiority, and the demand for new high sensitivity biosensors based on THz metamaterials is increasing. This paper presents a polarization-insensitive terahertz metamaterial sensor used for BSA detection. Simulation reveals that the peak of transmission spectrum shifts obviously when the sensor is covered with analytes of different refractive index and thickness. After the sensor is covered with 10 μm thick non-destructive analytes, its sensitivity is as high as 135 GHz/RIU. Experiments show that the lowest detectable concentration of BSA solutions by this sensor is 0.1 mg/mL, the peak red shift of the transmission spectrum reaches 137 GHz when the concentration is 17.6 mg/mL, and the frequency shift percentage is 16.4%. This study provides a highly sensitive solution for biosensor detection in the pharmaceutical and food fields.

中文翻译：

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用于牛血清白蛋白（BSA）检测的高灵敏度太赫兹超材料生物传感器

太赫兹（THz）超材料由于其独特的优越性被广泛应用于生物传感器器件中，对基于太赫兹超材料的新型高灵敏度生物传感器的需求日益增加。本文介绍了一种用于 BSA 检测的偏振不敏感太赫兹超材料传感器。仿真表明，当传感器覆盖有不同折射率和厚度的分析物时，透射光谱的峰值明显偏移。传感器被10 μm厚的非破坏性分析物覆盖后，其灵敏度高达135 GHz / RIU。实验表明，该传感器可检测的最低 BSA 溶液浓度为 0.1 mg/mL，当浓度为 17.6 mg/mL 时，透射光谱的峰值红移达到 137 GHz，频移百分比为 16.4%。