Background: Genital powder use is more common among African-American women; however, studies of genital powder use and ovarian cancer risk have been conducted predominantly in White populations, and histotype-specific analyses among African-American populations are limited. Methods: We used data from five studies in the Ovarian Cancer in Women of African Ancestry consortium. Participants included 620 African-American cases, 1,146 African-American controls, 2,800 White cases, and 6,735 White controls who answered questions on genital powder use prior to 2014. The association between genital powder use and ovarian cancer risk by race was estimated using logistic regression. Results: The prevalence of ever genital powder use for cases was 35.8% among African-American women and 29.5% among White women. Ever use of genital powder was associated with higher odds of ovarian cancer among African-American women [OR = 1.22; 95% confidence interval (CI) = 0.97–1.53] and White women (OR = 1.36; 95% CI = 1.19–1.57). In African-American women, the positive association with risk was more pronounced among high-grade serous tumors (OR = 1.31; 95% CI = 1.01–1.71) than with all other histotypes (OR = 1.05; 95% CI = 0.75–1.47). In White women, a significant association was observed irrespective of histotype (OR = 1.33; 95% CI = 1.12–1.56 and OR = 1.38; 95% CI = 1.15–1.66, respectively). Conclusions: While genital powder use was more prevalent among African-American women, the associations between genital powder use and ovarian cancer risk were similar across race and did not materially vary by histotype. Impact: This is one of the largest studies to date to compare the associations between genital powder use and ovarian cancer risk, overall and by histotype, between African-American and White women.

中文翻译：

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非洲血统妇女卵巢癌中生殖器粉末的使用和上皮性卵巢癌的风险


背景：使用生殖器粉末在非裔美国女性中更为常见；然而，关于生殖器粉末使用和卵巢癌风险的研究主要在白人群体中进行，而非洲裔美国人群体中的组织型特异性分析有限。方法：我们使用了非洲血统女性卵巢癌联盟五项研究的数据。参与者包括 620 名非裔美国人病例、1,146 名非裔美国人对照、2,800 名白人病例和 6,735 名白人对照，他们在 2014 年之前回答了有关生殖器粉末使用的问题。使用逻辑回归估计了生殖器粉末使用与按种族划分的卵巢癌风险之间的关联。结果：非洲裔美国女性中曾使用过生殖器粉末的比例为 35.8%，白人女性中为 29.5%。曾经使用过生殖器粉末与非洲裔美国女性患卵巢癌的较高风险相关[OR = 1.22； 95% 置信区间 (CI) = 0.97–1.53] 和白人女性（OR = 1.36；95% CI = 1.19–1.57）。在非裔美国女性中，高级别浆液性肿瘤与风险的正相关性（OR = 1.31；95% CI = 1.01–1.71）比所有其他组织型（OR = 1.05；95% CI = 0.75–1.47）更为明显。 ）。在白人女性中，无论组织型如何，都观察到显着相关性（分别为 OR = 1.33；95% CI = 1.12–1.56 和 OR = 1.38；95% CI = 1.15–1.66）。结论：虽然生殖器粉末的使用在非裔美国女性中更为普遍，但生殖器粉末的使用与卵巢癌风险之间的关联在不同种族中是相似的，并且不会因组织类型而存在重大差异。 影响：这是迄今为止规模最大的研究之一，旨在比较非洲裔美国女性和白人女性之间总体和按组织类型划分的生殖器粉末使用与卵巢癌风险之间的关联。