Sean Morrison has spent his career studying the mechanisms that regulate stem cell function and the ways in which these mechanisms influence cancer development. He has discovered several important regulators of stem cell self-renewal, as well as factors that influence the self-replication of cancer cells. In addition, Morrison has identified the location and cellular composition of the microenvironment of hematopoietic stem cells in adult bone marrow and spleen. Morrison’s work on hematopoietic stem cells led to the discovery of a bone-forming growth factor that he named osteolectin (1). In his Inaugural Article, Morrison describes recent work on the mechanisms by which osteolectin influences bone formation (2). Morrison is now an HHMI Investigator at the University of Texas Southwestern Medical Center and was elected to the National Academy of Sciences in 2020.

中文翻译：

---

肖恩·J·莫里森 QnA

肖恩·莫里森 (Sean Morrison) 的职业生涯一直在研究调节干细胞功能的机制以及这些机制影响癌症发展的方式。他发现了干细胞自我更新的几个重要调节因子，以及影响癌细胞自我复制的因素。此外，Morrison 还确定了成人骨髓和脾脏中造血干细胞微环境的位置和细胞组成。Morrison 在造血干细胞方面的工作导致发现了一种骨形成生长因子，他将其命名为骨凝集素 ( 1 )。在他的就职文章中，Morrison 描述了最近关于骨凝集素影响骨形成机制的工作 ( 2）。Morrison is now an HHMI Investigator at the University of Texas Southwestern Medical Center and was elected to the National Academy of Sciences in 2020.