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Unveiling the Functions of the VosA-VelB Target Gene vidD in Aspergillus nidulans
Mycobiology ( IF 1.6 ) Pub Date : 2021-06-21 , DOI: 10.1080/12298093.2021.1926122
Ye-Eun Son 1 , Hee-Soo Park 1, 2
Affiliation  

Abstract

The velvet regulators VosA and VelB are primarily involved in spore maturation and dormancy. Previous studies found that the VosA-VelB hetero-complex coordinates certain target genes that are related to fungal differentiation and conidial maturation in Aspergillus nidulans. Here, we characterized the VosA/VelB-inhibited developmental gene vidD in A. nidulans. Phenotypic analyses demonstrated that the vidD deleted mutant exhibited defect fungal growth, a reduced number of conidia, and delayed formation of sexual fruiting bodies. The deletion of vidD decreased the amount of conidial trehalose, increased the sensitivity against heat stress, and reduced the conidial viability. Moreover, the absence of vidD resulted in increased production of sterigmatocystin. Together, these results show that VidD is required for proper fungal growth, development, and sterigmatocystin production in A. nidulans.



中文翻译:

揭示构巢曲霉中 VosA-VelB 靶基因 vidD 的功能

摘要

所述天鹅绒调节沃萨和VelB主要参与孢子成熟和休眠。先前的研究发现,VosA-VelB 异源复合物协调某些与构巢曲霉中真菌分化和分生孢子成熟相关的靶基因。在这里,我们的特点沃萨/ VelB抑制的发育基因VIDD构巢曲霉。表型分析表明,vidD删除的突变体表现出真菌生长缺陷、分生孢子数量减少和有性子实体的形成延迟。vidD的删除减少分生孢子海藻糖的量,增加对热应激的敏感性,并降低分生孢子的活力。此外,视频的缺失导致 sterigmatocystin 的产生增加。总之,这些结果表明,构巢曲霉中适当的真菌生长、发育和 sterigmatocystin 生产需要 VidD 。

更新日期:2021-07-02
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