The development of regenerative therapy for human spinal cord injury (SCI) is dramatically restricted by two main challenges: the need for a safe source of functionally active and reproducible neural stem cells and the need of adequate animal models for preclinical testing. Direct reprogramming of somatic cells into neuronal and glial precursors might be a promising solution to the first challenge. The use of non-human primates for preclinical studies exploring new treatment paradigms in SCI results in data with more translational relevance to human SCI.

中文翻译：

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在非人类灵长类动物中使用直接重编程的神经前体细胞对脊髓损伤进行疾病修饰治疗。

人类脊髓损伤 (SCI) 再生疗法的发展受到两个主要挑战的极大限制：需要安全的功能活性和可再生神经干细胞来源，以及需要足够的动物模型进行临床前测试。将体细胞直接重编程为神经元和神经胶质前体可能是应对第一个挑战的有希望的解决方案。使用非人类灵长类动物进行临床前研究，探索 SCI 中的新治疗范式，从而产生与人类 SCI 具有更多转化相关性的数据。