Organic chemicals identified in raw landfill leachate (LL) and their transformation products (TPs), formed during Fenton treatment, were analyzed for chemical safety following REACH guidelines. The raw LL was located in the metropolitan region of Campina Grande, in northeast Brazil. We elucidated 197 unique chemical structures, including 154 compounds that were present in raw LL and 82 compounds that were detected in the treated LL, totaling 39 persistent compounds and 43 TPs. In silico models were developed to identify and prioritize the potential level of hazard/risk these compounds pose to the environment and society. The models revealed that the Fenton process improved the biodegradability of TPs. Still, a slight increase in ecotoxicological effects was observed among the compounds in treated LL compared with those present in raw LL. No differences were observed for aryl hydrocarbon receptor (AhR) and antioxidant response element (ARE) mutagenicity. Similar behavior among both raw and treated LL samples was observed for biodegradability; Tetrahymena pyriformis, Daphnia magna, Pimephales promelas and ARE, AhR, and Ames mutagenicity. Overall, our results suggest that raw and treated LL samples have similar activity profiles for all endpoints other than biodegradability.

在 Fenton 处理过程中形成的原始垃圾填埋渗滤液 (LL) 及其转化产物 (TP) 中确定的有机化学物质，按照 REACH 指南进行化学安全性分析。原始 LL 位于巴西东北部的 Campina Grande 大都市区。我们阐明了 197 种独特的化学结构，包括原始 LL 中存在的 154 种化合物和处理过的 LL 中检测到的 82 种化合物，总共 39 种持久性化合物和 43 TP。电脑模拟开发了模型来确定这些化合物对环境和社会造成的危害/风险的潜在水平并对其进行优先排序。模型显示芬顿工艺提高了 TP 的生物降解性。尽管如此，与原始 LL 中存在的化合物相比，在处理过的 LL 中的化合物中观察到生态毒理学效应略有增加。未观察到芳烃受体 (AhR) 和抗氧化反应元件 (ARE) 致突变性的差异。在生物降解性方面，观察到原始和处理过的 LL 样品之间的相似行为；Tetrahymena pyriformis、Daphnia magna、Pimephales promelas和 ARE、AhR 和 Ames 致突变性。总体而言，我们的结果表明，原始和处理过的 LL 样品在除生物降解性之外的所有终点都具有相似的活性特征。