Autoimmune thyroid disease (AITD) is more common among diabetes mellitus (DM) patients and may impact its microvascular complications. The present study aimed to assess the relationship between AITD and the prevalence of diabetic kidney disease (DKD) in patients with diabetes mellitus type 1 (DM1). Anthropometric parameters, parameters of metabolic control of DM, thyreometabolic status, and the UACR were assessed. DKD was diagnosed if patients’ UACR level was ≥30 mg/g or eGFR level was <60 mL/min. This study involved 144 patients with DM1 aged 36.2 ± 11.7 years: 49 men and 95 women. Significant differences in creatinine, eGFR, and UACR levels were found in patients with DKD. fT3 concentration was significantly lower among DKD patients. A significantly higher probability of DKD was found in DM1 patients with lower fT3 levels. Patients with DM1 and AITD had significantly lower creatinine levels than the control group. However, the study did not show any significant relationship between AITD and the occurrence of DKD in patients with DM1. Significantly lower fT3 concentrations in DKD patients may be caused by metabolic disorders in the course of DKD and require further cohort studies in a larger population of patients with DM1 and AITD.

中文翻译：

---

自身免疫性甲状腺疾病的患病率与糖尿病肾病之间是否存在关系？

自身免疫性甲状腺疾病（AITD）在糖尿病（DM）患者中更为常见，可能会影响其微血管并发症。本研究旨在评估 1 型糖尿病 (DM1) 患者中 AITD 与糖尿病肾病 (DKD) 患病率之间的关系。评估人体测量参数、糖尿病代谢控制参数、甲状腺代谢状态和 UACR。如果患者的UACR水平≥30 mg/g或eGFR水平<60 mL/min，则诊断为DKD。这项研究涉及 144 名年龄 36.2 ± 11.7 岁的 DM1 患者：49 名男性和 95 名女性。DKD 患者的肌酐、eGFR 和 UACR 水平存在显着差异。DKD 患者的 fT3 浓度显着较低。fT3 水平较低的 1 型糖尿病患者患 DKD 的可能性显着较高。DM1 和 AITD 患者的肌酐水平显着低于对照组。然而，该研究并未显示DM1患者AITD与DKD的发生之间存在任何显着关系。DKD 患者中 fT3 浓度显着降低可能是由 DKD 病程中的代谢紊乱引起的，需要在更多的 DM1 和 AITD 患者中进行进一步的队列研究。