The purpose of this study was to investigate whether the Dictyophora echinovolvata spore polysaccharides (DESP) affect the immunity in immunocompromised mice induced by cyclophosphamide (CTX). The healthy female Kunming mice were randomly divided into six groups, including a normal control (NC) group, a positive control group, a model control (MC) group, and three groups treated with low-, intermediate-, and high-dose polysaccharide, respectively. A series of immunoregulatory properties were determined, including humoral and cellular immunity, immune function, and immune factors of mononuclear macrophages. Compared with NC and MC groups, treatment with DESP significantly increased the spleen index and decreased the thymus index; increased the serum concentrations of immunoglobulin (Ig)A, IgG, IgM, hemolysin, IL-1β, and IL-2; delayed the allergic reaction; and improved the splenic lymphocyte transformation ability; and enhanced the phagocytosis of macrophages and the ability to secrete IL-6, TNF-α, caspase-1, and NO with DESP supplementation. These results indicated that DESP might have a good regulatory effect on CTX-induced immunodeficiency in mice, adjust the body’s immune imbalance, and improve the symptoms of low immunity.

中文翻译：

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棘皮蠃孢子多糖对环磷酰胺致免疫功能低下小鼠的免疫调节作用

本研究的目的是研究 Dictyophora echinovolvata 孢子多糖 (DESP) 是否影响由环磷酰胺 (CTX) 诱导的免疫功能低下小鼠的免疫力。将健康雌性昆明小鼠随机分为六组，包括正常对照组（NC）、阳性对照组、模型对照组（MC）和低、中、高剂量多糖处理三组。 ， 分别。确定了一系列免疫调节特性，包括体液和细胞免疫、免疫功能和单核巨噬细胞的免疫因子。与NC组和MC组相比，DESP治疗显着增加脾脏指数，降低胸腺指数；增加免疫球蛋白 (Ig)A、IgG、IgM、溶血素、IL-1β 和 IL-2 的血清浓度；延迟过敏反应；提高脾淋巴细胞转化能力；并通过补充 DESP 增强巨噬细胞的吞噬作用和分泌 IL-6、TNF-α、caspase-1 和 NO 的能力。这些结果表明，DESP可能对CTX诱导的小鼠免疫缺陷有良好的调节作用，调节机体免疫失衡，改善免疫力低下的症状。