Introduction. Chronic inflammation and oxidative stress conditions have been reported in women with polycystic ovary syndrome (PCOS). Peroxiredoxin 4 (Prx4) is a related antioxidant in insulin synthesis. We hypothesized that insulin resistance in these women is associated with total oxidant status (TOS) and inflammatory factors. Materials and Methods. Two hundred three people including 104 PCOS patients and 99 healthy women, who were matched for age and body mass index (BMI), entered the study. Waist circumference of the participants was measured; serum glucose, lipid profile, insulin, Prx4, TOS, hs-CRP, and TNF-α were also evaluated. Results. The Prx4 level was significantly lower in PCOS than in the control group. In addition, marked increase was observed in the concentration of TOS, hs-CRP, and TNF-α in PCOS, compared to the healthy women. There was a positive correlation of TOS with hs-CRP, TNF-α, and HOMA-IR. The risk of PCOS for subjects with high hs-CRP was 60 times greater than those who had low serum hs-CRP concentration; after performing multiple logistic regression analyses with the backward method, TNF-α was considered as an effective biomarker to predict PCOS β = 49.087 (all ). Conclusion. This study identified increased oxidative stress and inflammation in PCOS; this may be due to decrease in the antioxidants, such as Prx4.

中文翻译：

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Prx4、总氧化状态和炎症因子与多囊卵巢综合征胰岛素抵抗的关联


介绍。据报道，患有多囊卵巢综合症（PCOS）的女性会出现慢性炎症和氧化应激状况。过氧化还原蛋白 4 (Prx4) 是胰岛素合成中的相关抗氧化剂。我们假设这些女性的胰岛素抵抗与总氧化状态（TOS）和炎症因子有关。材料和方法。 203 人参与了这项研究，其中包括 104 名 PCOS 患者和 99 名健康女性，她们的年龄和体重指数 (BMI) 相匹配。测量参与者的腰围；还评估了血清葡萄糖、血脂、胰岛素、Prx4、TOS、hs-CRP 和 TNF- α 。结果。 PCOS 组的 Prx4 水平显着低于对照组。此外，与健康女性相比，PCOS 患者的 TOS、hs-CRP 和 TNF- α浓度显着增加。 TOS与hs-CRP、TNF- α 、HOMA-IR呈正相关。高hs-CRP受试者患PCOS的风险比血清hs-CRP浓度低的受试者高60倍；用后向法进行多重逻辑回归分析后，TNF- α被认为是预测PCOS β = 49.087的有效生物标志物（所有 ）。结论。这项研究发现多囊卵巢综合症患者的氧化应激和炎症增加；这可能是由于 Prx4 等抗氧化剂的减少所致。