当前位置: X-MOL 学术J. Anal. Toxicol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Cannabinoids Tetrahydrocannabinol, Cannabinol, Cannabidiol, Tetrahydrocannabivarin and 11-nor-9-carboxy-∆9-THC in Hair
Journal of Analytical Toxicology ( IF 2.3 ) Pub Date : 2021-06-21 , DOI: 10.1093/jat/bkab068
Virginia A Hill 1 , Michael I Schaffer 1 , Ryan B Paulsen 1 , G Neil Stowe 1
Affiliation  

The cannabinoids tetrahydrocannabinol (THC), tetrahydrocannabivarin (THCV), cannabidiol (CBD), cannabinol (CBN) and (-)-11-nor-9-carboxy-∆9-tetrahydrocannabinol (THC-COOH) were determined in 4,773 hair samples. Confirmation of THC-COOH was by GC–MS-MS (gas chromatography-mass spectrometry-mass spectrometry). Confirmation of THC, THCV, CBN and CBD was by LC–MS-MS (liquid chromatoraphy-mass spectrometry-mass spectrometry) on an AB Sciex QTRAP 6500+ LC–MS-MS. The purpose of this work was not to utilize any analyte other than THC-COOH as indicative of ingestion, but to assess the absence or presence, and relative concentrations, of the other cannabinoid analytes in hair of marijuana users vs. primarily CBD users. In this regard, 10% of samples contained significantly higher concentrations of CBD relative to THC than the other 90%. A concentration of CBD that is five times greater than that of THC was proposed as good evidence of primarily CBD ingestion. THC concentrations in the samples ranged from below the limit of detection (5 pg/mg) to 47,808 pg/mg hair, varying widely in the relationship between parent THC and the metabolite THC-COOH. CBN was present in most samples, but concentrations relative to THC decreased with increasing THC concentrations. Only 26% of the samples contained THCV detectable by the method. When present, THCV concentrations averaged 1.77% of THC. A limitation of this study is the lack of subject histories to determine the types and amounts of products used and the mode of ingestion. Also, not all THC from external contamination may be removed. Nonetheless, the data provide a useful guide as to what cannabinoids may be found in hair, at what concentrations and under conditions of marijuana use vs. likely primarily CBD use.

中文翻译:

头发中的大麻素四氢大麻酚、大麻酚、大麻二酚、四氢大麻酚和 11-nor-9-carboxy-∆9-THC

在 4,773 个头发样本中测定了大麻素四氢大麻酚 (THC)、四氢大麻酚 (THCV)、大麻二酚 (CBD)、大麻酚 (CBN) 和 (-)-11-nor-9-羧基-Δ9-四氢大麻酚 (THC-COOH)。THC-COOH 的确认是通过 GC-MS-MS(气相色谱-质谱-质谱)。THC、THCV、CBN 和 CBD 的确认是通过 AB Sciex QTRAP 6500+ LC-MS-MS 上的 LC-MS-MS(液相色谱-质谱-质谱)。这项工作的目的不是利用 THC-COOH 以外的任何分析物作为摄入的指示物,而是评估大麻使用者与主要 CBD 使用者头发中其他大麻素分析物的不存在或存在以及相对浓度。在这方面,与其他 90% 相比,10% 的样本中 CBD 的浓度明显高于 THC。CBD 的浓度是 THC 浓度的五倍,这被认为是主要摄入 CBD 的良好证据。样品中的 THC 浓度范围从低于检测限 (5 pg/mg) 到 47,808 pg/mg 头发,母体 THC 和代谢物 THC-COOH 之间的关系变化很大。CBN 存在于大多数样品中,但相对于 THC 的浓度随着 THC 浓度的增加而降低。只有 26% 的样本含有该方法可检测到的 THCV。当存在时,THCV 浓度平均为 THC 的 1.77%。这项研究的一个局限性是缺乏受试者历史来确定所用产品的类型和数量以及摄入方式。此外,并非所有来自外部污染的 THC 都可以去除。尽管如此,这些数据为头发中可能含有哪些大麻素提供了有用的指导,
更新日期:2021-06-21
down
wechat
bug