Recent regenerative medicine studies have emphasized the need for increased standardization, harmonization and sharing of information related to stem cell product characterization, to help drive these innovative interventions toward public availability and to increase collaboration in the scientific community. Although numerous attempts and numerous databases have been made to manage these data, a platform that incorporates all the heterogeneous data collected from stem cell projects into a harmonized project-based framework is still lacking. The aim of the database, which is described in this study, is to provide an intelligent informatics solution that integrates comprehensive characterization of diverse stem cell product characteristics with research subject and project outcome information. In the resulting platform, heterogeneous data are validated using predefined ontologies and stored in a relational database, to ensure data quality and ease of access. Testing was performed using 51 published, publically available induced pluripotent stem cell projects conducted in clinical, preclinical and in-vitro evaluations. Future aims of this project include further increasing the database size to include all published stem cell trials and develop additional data visualization tools to improve usability. Our testing demonstrated the robustness of the proposed platform, by seamlessly harmonizing diverse common data elements, and the potential of this platform for driving knowledge generation from the aggregation and harmonization of these diverse data. Database URL https://remedy.mssm.edu/

中文翻译：

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ReMeDy：整合和共享已发表干细胞研究数据的平台，重点关注 iPSC 试验


最近的再生医学研究强调需要加强与干细胞产品表征相关的信息的标准化、协调和共享，以帮助推动这些创新干预措施向公众开放，并加强科学界的合作。尽管已经进行了大量尝试和大量数据库来管理这些数据，但仍然缺乏一个将从干细胞项目收集的所有异构数据整合到基于项目的协调框架中的平台。本研究中描述的数据库的目的是提供一种智能信息学解决方案，将各种干细胞产品特性的综合表征与研究主题和项目成果信息相结合。在最终的平台中，异构数据使用预定义的本体进行验证并存储在关系数据库中，以确保数据质量和易于访问。使用 51 个已发表、公开的诱导多能干细胞项目进行临床、临床前和体外评估进行测试。该项目的未来目标包括进一步增加数据库大小以包含所有已发表的干细胞试验，并开发额外的数据可视化工具以提高可用性。我们的测试通过无缝协调不同的通用数据元素证明了所提出的平台的稳健性，以及该平台通过这些不同数据的聚合和协调来驱动知识生成的潜力。数据库网址 https://remedy.mssm.edu/