Highly effective antimicrobial properties of triclosan (TCS) make its use as a widely used preservative in different types of consumer products. TCS is reported as an emerging endocrine disruptor causing reproductive impairments in the males as well as in the females. The present study describes the adverse effects of various doses of TCS (40, 80, 160 and 320 mg/kg BW/day, for 42 consecutive days) on the weights and histopathology of the epididymis and seminal vesicle, sperm indices (motility, viability, count and morphology), concentrations of epididymal sialic acid and seminal vesicular fructose, along with TCS accumulated in these accessory reproductive organs of the laboratory mouse. TCS induced significant reductions in the weights of the epididymis and seminal vesicle along with noticeable histopathological alterations in these organs. TCS caused significant reductions in the count, percentage of motile and viable spermatozoa while a significant increase in the percentage of abnormal spermatozoa in the epididymis. Concentrations of epididymal sialic acid and seminal vesicular fructose declined significantly in the treated mice. A significant increase was noticed in the concentration of TCS, accumulated in the epididymis and seminal vesicle following TCS exposure at a high dose (320 mg/kg BW/day). The results thus suggest that the accessory sex organs are also affected deleteriously following TCS exposure, leading to impairment in the male reproductive health.

三氯生 (TCS) 的高效抗菌特性使其在不同类型的消费品中用作广泛使用的防腐剂。据报道，TCS 是一种新兴的内分泌干扰物，可导致男性和女性的生殖障碍。本研究描述了不同剂量 TCS（40、80、160 和 320 mg/kg BW/天，连续 42 天）对附睾和精囊的重量和组织病理学、精子指数（运动性、活力，计数和形态），附睾唾液酸和精囊果糖的浓度，以及在实验室小鼠的这些辅助生殖器官中积累的 TCS。TCS 引起附睾和精囊重量的显着降低以及这些器官的明显组织病理学改变。治疗小鼠的附睾唾液酸和精囊果糖浓度显着下降。在以高剂量（320 mg/kg BW/天）接触 TCS 后，在附睾和精囊中积累的 TCS 浓度显着增加。因此，结果表明，在 TCS 暴露后，附属性器官也会受到有害影响，导致男性生殖健康受损。治疗小鼠的附睾唾液酸和精囊果糖浓度显着下降。在以高剂量（320 mg/kg BW/天）接触 TCS 后，在附睾和精囊中积累的 TCS 浓度显着增加。因此，结果表明，在 TCS 暴露后，附属性器官也会受到有害影响，导致男性生殖健康受损。