To our knowledge, no study has been carried out to evaluate the effects of thymol sustained administration on gut health and immune response in terms of its bioavailability in the rabbit organism. A total of 48 rabbits were randomly divided at 35 days of age into two dietary treatment groups (C/control or T/thymol at 0.025% addition). Thymol was added for 21 days and then withdrawn for 7 days. Thymol content in faeces (p < 0.001) and caecal content (p < 0.05) was significantly higher than in plasma during the thymol addition and withdrawal (2442 ± 451.4, 881.9 ± 231.3 ng/g DM and 46.2 ± 28.4 ng/ml, respectively; 149.5 ± 40.54, 45.76 ± 12.44 ng/g DM and 2.73 ± 0.45 ng/ml, respectively). Increasing of villi height to crypt depth ratio in small intestinal wall (p < 0.01), phagocytic activity in blood (p < 0.0001) and lactic acid bacteria in caecal appendix (p < 0.01) and faeces (p < 0.05) was still presented after withdrawn of thymol. The thymol at this concentration demonstrated its biological properties and was able to positively affect gut health and immune response of rabbits.

中文翻译：

---

育肥兔日粮中的百里酚、其生物利用度及其对肠道形态、盲肠微生物群和免疫的影响

据我们所知，还没有研究评估百里酚持续给药对兔体内的生物利用度对肠道健康和免疫反应的影响。总共 48 只兔子在 35 日龄时被随机分为两个饮食治疗组（C/对照或 T/百里酚，添加量为 0.025%）。加入百里酚 21 天，然后停止 7 天。在百里酚添加和停止期间，粪便中的百里酚含量 ( p  < 0.001) 和盲肠中的百里酚含量 ( p  < 0.05) 显着高于血浆（分别为 2442 ± 451.4、881.9 ± 231.3 ng/g DM 和 46.2 ± 28.4 ng/ml ; 149.5 ± 40.54、45.76 ± 12.44 ng/g DM 和 2.73 ± 0.45 ng/ml）。小肠壁绒毛高度与隐窝深度比的增加 ( p < 0.01),百里酚停药后血液( p < 0.0001)和盲肠阑尾( p  < 0.01)和粪便( p < 0.05)中 的乳酸菌仍存在 吞噬活性。该浓度的百里酚显示出其生物学特性，并能够对兔子的肠道健康和免疫反应产生积极影响。