Reduced laser-evoked potential (LEP) habituation indicates abnormal central pain processing. But the paradigm (four stimulation blocks a 25 stimuli) is time consuming and potentially omits important information on the exact habituation time course. This study examined whether a high temporal resolution (HTR) analysis (dividing the four stimulation blocks into 12 analysis blocks) can answer the following questions: (a) After how many stimuli does LEP habituation occur? (b) Is there a difference in LEP habituation in younger versus older subjects? (c) Is HTR applicable on radiculopathy patients?

中文翻译：

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通过高时间分辨率分析揭示激光诱发电位习惯的时间过程

降低的激光诱发电位 (LEP) 习惯表明中枢疼痛处理异常。但是范式（四个刺激块一个 25 个刺激）是耗时的，并且可能会忽略关于确切习惯时间过程的重要信息。本研究检验了高时间分辨率 (HTR) 分析（将四个刺激块划分为 12 个分析块）是否可以回答以下问题：(a) LEP 习惯化在多少次刺激后发生？(b) 年轻受试者与老年受试者的 LEP 习惯是否存在差异？(c) HTR 是否适用于神经根病患者？