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Identification of OCA2 as a novel locus for the co-morbidity of asthma-plus-eczema
Clinical & Experimental Allergy ( IF 6.3 ) Pub Date : 2021-06-22 , DOI: 10.1111/cea.13972 Patricia Margaritte-Jeannin 1 , Ashley Budu-Aggrey 2 , Markus Ege 3 , Anne-Marie Madore 4 , Christophe Linhard 1 , Hamida Mohamdi 1 , Erika von Mutius 3 , Raquel Granell 2 , Florence Demenais 1 , Catherine Laprise 4 , Emmanuelle Bouzigon 1 , Marie-Hélène Dizier 1
Clinical & Experimental Allergy ( IF 6.3 ) Pub Date : 2021-06-22 , DOI: 10.1111/cea.13972 Patricia Margaritte-Jeannin 1 , Ashley Budu-Aggrey 2 , Markus Ege 3 , Anne-Marie Madore 4 , Christophe Linhard 1 , Hamida Mohamdi 1 , Erika von Mutius 3 , Raquel Granell 2 , Florence Demenais 1 , Catherine Laprise 4 , Emmanuelle Bouzigon 1 , Marie-Hélène Dizier 1
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Numerous genes have been associated with the three most common allergic diseases (asthma, allergic rhinitis or eczema) but these genes explain only a part of the heritability. In the vast majority of genetic studies, complex phenotypes such as co-morbidity of two of these diseases, have not been considered. This may partly explain missing heritability.
中文翻译：
将 OCA2 鉴定为哮喘加湿疹合并症的新基因座
许多基因与三种最常见的过敏性疾病（哮喘、过敏性鼻炎或湿疹）有关，但这些基因仅解释了遗传力的一部分。在绝大多数遗传研究中，尚未考虑复杂的表型，例如其中两种疾病的共病。这可能部分解释了遗传力的缺失。
更新日期：2021-06-22
中文翻译：
将 OCA2 鉴定为哮喘加湿疹合并症的新基因座
许多基因与三种最常见的过敏性疾病（哮喘、过敏性鼻炎或湿疹）有关，但这些基因仅解释了遗传力的一部分。在绝大多数遗传研究中，尚未考虑复杂的表型，例如其中两种疾病的共病。这可能部分解释了遗传力的缺失。
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