Annual Review of Biochemistry ( IF 12.1 ) Pub Date : 2021-06-21 , DOI: 10.1146/annurev-biochem-010421-023239 Gunnar von Heijne 1
This volume of the Annual Review of Biochemistry contains three reviews on membrane channel proteins: the first by Szczot et al., titled The Form and Function of PIEZO2; the second by Ruprecht & Kunji, titled Structural Mechanism of Transport of Mitochondrial Carriers; and the third by McIlwain et al., titled Membrane Exporters of Fluoride Ion. These reviews provide nice illustrations of just how far evolution has been able to play with the basic helix-bundle architecture of integral membrane proteins to produce membrane channels and transporters of widely different functions.
中文翻译:
膜频道主题介绍
本卷生物化学年度评论包含三篇关于膜通道蛋白的评论:第一篇由 Szczot 等人撰写,标题为 PIEZO2 的形式和功能;Ruprecht & Kunji 的第二个,题为 Structural Mechanism of Transport of Mitochondrial Carriers;第三个由 McIlwain 等人撰写,题为氟离子的膜出口商。这些评论很好地说明了进化能够在多大程度上利用整合膜蛋白的基本螺旋束结构来产生具有广泛不同功能的膜通道和转运蛋白。