Epilepsy is a problematic neurological disorder combined with recurrent seizures, and gabapentin is a vital antiepileptic drug proposed for the treatment of many neuropathic pains. However, the bioavailability of this drug decreases with enhancing dose and may alter the central nervous system and induces different side effects. Therefore, design and fabrication of visible-light sensitive nanocarriers for this drug are being demanded in the few past years. Herein, gold and silver nanoparticles are synthesized through the simple Turkevich method and characterized by TEM, DLS, XRD and UV–Vis techniques. The XRD and TEM analyses confirmed formation of the face-centered cubic Au and Ag crystalline phases with 20–30 nm in size. Then, the prepared nanoparticles are used as drug-loadable nanospheres (DLNs) for gabapentin in an aqueous colloidal solution. It is found that the characteristic surface plasmonic resonance (SPR) peaks of the DLNs loaded with gabapentin (DLNs-LG) are strongly dependent on the concentration of the loaded drug. Moreover, the SPR and drug-release behavior of the DLNs-LG are investigated upon three different light sources (red, green, and blue). The obtained results show that the most efficient way to release the maximum amount of drug is to adopt the wavelength of the light source with the SPR peak of the synthesized DLNs-LG. A sensible hypsochromic blue shift is also observed by increasing the irradiation time on the DLNs-LG NPs, establishing the time-dependent nature of the drug-release process. Moreover, the performed numerical calculations exhibit interesting information on the loading and release processes and an equation is finally derived to qualitatively evaluate the amount of the detached drug from DLNs-LG NPs. Furthermore, it is found that the green light is favored for Au NPs; whereas the blue LED source is preferred for Ag NPs to achieve the best release efficiency. The outputs of this study can be useful to understand the influence of light irradiation on the drug-loaded nanoparticles in order to introduce a new method to study drug release/loading mechanisms onto Au and Ag NPs.

癫痫是一种有问题的神经系统疾病，伴有反复发作，加巴喷丁是一种重要的抗癫痫药物，被提议用于治疗许多神经性疼痛。然而，这种药物的生物利用度随着剂量的增加而降低，并可能改变中枢神经系统并引起不同的副作用。因此，在过去几年中需要设计和制造用于该药物的可见光敏感纳米载体。在此，金和银纳米粒子通过简单的 Turkevich 方法合成，并通过 TEM、DLS、XRD 和 UV-Vis 技术进行表征。XRD 和 TEM 分析证实形成了尺寸为 20-30 nm 的面心立方 Au 和 Ag 结晶相。然后，将制备的纳米颗粒用作胶体水溶液中加巴喷丁的载药纳米球（DLN）。发现负载加巴喷丁 (DLNs-LG) 的 DLN 的特征表面等离子体共振 (SPR) 峰强烈依赖于负载药物的浓度。此外，在三种不同的光源（红色、绿色和蓝色）下研究了 DLNs-LG 的 SPR 和药物释放行为。所得结果表明，释放最大量药物的最有效方式是采用具有合成DLNs-LG SPR峰的光源波长。通过增加对 DLNs-LG NPs 的照射时间，也观察到了明显的减色蓝移，确定了药物释放过程的时间依赖性。而且，所进行的数值计算展示了有关加载和释放过程的有趣信息，最终推导出一个方程来定性评估从 DLNs-LG NPs 上分离的药物量。此外，发现绿光有利于 Au NPs；而蓝色 LED 光源是 Ag NPs 的首选，以实现最佳的释放效率。这项研究的结果有助于了解光照射对载药纳米颗粒的影响，以便引入一种新方法来研究 Au 和 Ag NPs 上的药物释放/装载机制。