Inflammasome activation and IL-1β signalling in group A Streptococcus disease,Cellular Microbiology

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Inflammasome activation and IL-1β signalling in group A Streptococcus disease
Cellular Microbiology ( IF 2.6 ) Pub Date : 2021-06-21 , DOI: 10.1111/cmi.13373
Johanna Richter ₁ , Stephan Brouwer ₁ , Kate Schroder ₂ , Mark J Walker ₁

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Group A Streptococcus (GAS) is a Gram-positive bacterial pathogen that causes significant morbidity and mortality worldwide. Recent clinical evidence suggests that the inflammatory marker interleukin-1β (IL-1β) plays an important role in GAS disease progression, and presents a potential target for therapeutic intervention. Interaction with GAS activates the host inflammasome pathway to stimulate production and secretion of IL-1β, but GAS can also stimulate IL-1β production in an inflammasome-independent manner. This review highlights progress that has been made in understanding the importance of host cell inflammasomes and IL-1 signalling in GAS disease, and explores challenges and unsolved problems in this host-pathogen interaction.

中文翻译：

A组链球菌病中的炎性体激活和IL-1β信号传导

A 组链球菌(GAS) 是一种革兰氏阳性细菌病原体，在全球范围内引起显着的发病率和死亡率。最近的临床证据表明，炎症标志物白细胞介素-1β (IL-1β) 在 GAS 疾病进展中起重要作用，并为治疗干预提供了潜在的靶点。与 GAS 的相互作用激活宿主炎症小体通路以刺激 IL-1β 的产生和分泌，但 GAS 也可以以非炎症小体的方式刺激 IL-1β 的产生。这篇综述强调了在理解宿主细胞炎症小体和 IL-1 信号在 GAS 疾病中的重要性方面取得的进展，并探讨了这种宿主-病原体相互作用中的挑战和未解决的问题。

更新日期：2021-08-17

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