Pulmonary fibrosis (PF) is the devastating consequence of various inflammatory diseases of the lung. PF leads to a reduction of lung function, respiratory failure, and death. Several molecular pathways are involved in PF, such as inflammatory cytokines including tumor necrosis factor α (TNFα), tumor necrosis factor β1 (TNFβ1), interleukin 6 (IL-6), and interleukin 4 (IL-4), reactive oxygen species, matrix metalloproteases, and transforming growth factor-beta (TGF-β). Targeting these processes involved in the progression of PF is essential for the treatment of this disease. Natural products, including plant extracts and active compound that directly target the processes involved in PF, could be suitable therapeutic options with less adverse effects. In the present study, we reviewed the protective effects and the therapeutic role of various bioactive compounds from plants in PF management.

肺纤维化 (PF) 是肺部各种炎症性疾病的破坏性后果。PF 导致肺功能下降、呼吸衰竭和死亡。PF 涉及多种分子通路，如炎症细胞因子，包括肿瘤坏死因子 α (TNFα)、肿瘤坏死因子 β1 (TNFβ1)、白介素 6 (IL-6) 和白介素 4 (IL-4)、活性氧、基质金属蛋白酶和转化生长因子-β (TGF-β)。靶向这些参与 PF 进展的过程对于治疗这种疾病至关重要。天然产品，包括直接针对 PF 所涉及过程的植物提取物和活性化合物，可能是合适的治疗选择，且副作用较小。在目前的研究中，