The review aims to summarize and discuss the current knowledge on targeting senescent cells to reduce the risk of age-related diseases in animal models and human studies. The role of cellular senescence in aging and the major age-related diseases -including Alzheimer's disease, atherosclerosis, and type 2 diabetes- as well as the use of senotherapeutic strategies in both experimental and preclinical studies, will be described. A large number of molecules, including synthetic agents and natural compounds, have been proposed for anti-senescence activities. Research on senotherapeutics, which includes senolytic and senomorphic, has a growing interest, and their safety and reliability as anti-aging drugs have been tested in clinical trials. Initial findings suggest that the senotherapeutic approach may be translatable to humans. Due to the lack of evidence, caution must be used against senolytic agents due to their potential side-effects. In this context, natural senolytic compounds should have the advantage of low toxicity and potentially more useful in humans, although the mechanisms of action need to be defined.

该综述旨在总结和讨论目前关于靶向衰老细胞以降低动物模型和人体研究中年龄相关疾病风险的知识。将描述细胞衰老在衰老和主要与年龄相关的疾病（包括阿尔茨海默病、动脉粥样硬化和 2 型糖尿病）中的作用，以及在实验和临床前研究中使用衰老治疗策略。已经提出了大量的分子，包括合成剂和天然化合物，用于抗衰老活性。对包括senolytic和senomorphic在内的senotherapeutics的研究越来越受到关注，其作为抗衰老药物的安全性和可靠性已在临床试验中得到检验。初步研究结果表明，senotherapeutic 方法可能适用于人类。由于缺乏证据，因此必须谨慎使用抗衰老药物，因为它们具有潜在的副作用。在这种情况下，天然抗衰老化合物应该具有低毒性的优点，并且可能对人类更有用，尽管需要确定作用机制。