The skin is comprised of different cell types with different proliferative capacities. Skin aging occurs with chronological age and upon exposure to extrinsic factors such as photodamage. During aging, senescent cells accumulate in different compartments of the human skin, leading to impaired skin physiology. Diverse skin cell types may respond differently to senescence-inducing stimuli and it is not clear how this results in aging-associated skin phenotypes and pathologies. This review aims to examine and provide an overview of current evidence of cellular senescence in the skin. We will focus on cellular characteristics and behaviour of different skin cell types undergoing senescence in the epidermis and dermis, with a particular focus on the complex interplay between mitochondrial dysfunction, autophagy and DNA damage pathways. We will also examine how the dermis and epidermis cope with the accumulation of DNA damage during aging.

皮肤由具有不同增殖能力的不同细胞类型组成。皮肤老化随着实际年龄和暴露于光损伤等外在因素而发生。在衰老过程中，衰老细胞会在人体皮肤的不同部位积聚，从而导致皮肤生理机能受损。不同的皮肤细胞类型可能对诱导衰老的刺激有不同的反应，目前尚不清楚这如何导致与衰老相关的皮肤表型和病理。本综述旨在检查并概述皮肤细胞衰老的当前证据。我们将专注于在表皮和真皮中经历衰老的不同皮肤细胞类型的细胞特征和行为，特别关注线粒体功能障碍、自噬和 DNA 损伤途径之间的复杂相互作用。