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The promising shadow of microbubble over medical sciences: from fighting wide scope of prevalence disease to cancer eradication
Journal of Biomedical Science ( IF 9.0 ) Pub Date : 2021-06-21 , DOI: 10.1186/s12929-021-00744-4
Ali Jangjou 1 , Amir Hossein Meisami 2 , Kazem Jamali 3 , Mohammad Hadi Niakan 3 , Milad Abbasi 4 , Mostafa Shafiee 4 , Majid Salehi 5, 6 , Ahmad Hosseinzadeh 7 , Ali Mohammad Amani 4 , Ahmad Vaez 8
Affiliation  

Microbubbles are typically 0.5–10 μm in size. Their size tends to make it easier for medication delivery mechanisms to navigate the body by allowing them to be swallowed more easily. The gas included in the microbubble is surrounded by a membrane that may consist of biocompatible biopolymers, polymers, surfactants, proteins, lipids, or a combination thereof. One of the most effective implementation techniques for tiny bubbles is to apply them as a drug carrier that has the potential to activate ultrasound (US); this allows the drug to be released by US. Microbubbles are often designed to preserve and secure medicines or substances before they have reached a certain area of concern and, finally, US is used to disintegrate microbubbles, triggering site-specific leakage/release of biologically active drugs. They have excellent therapeutic potential in a wide range of common diseases. In this article, we discussed microbubbles and their advantageous medicinal uses in the treatment of certain prevalent disorders, including Parkinson's disease, Alzheimer's disease, cardiovascular disease, diabetic condition, renal defects, and finally, their use in the treatment of various forms of cancer as well as their incorporation with nanoparticles. Using microbubble technology as a novel carrier, the ability to prevent and eradicate prevalent diseases has strengthened the promise of effective care to improve patient well-being and life expectancy.

中文翻译:

微气泡给医学带来的光明前景:从对抗广泛流行的疾病到根除癌症

微泡的尺寸通常为 0.5–10 μm。它们的尺寸往往使药物输送机制更容易在体内导航,从而更容易被吞咽。包含在微泡中的气体被膜包围,该膜可以由生物相容性生物聚合物、聚合物、表面活性剂、蛋白质、脂质或其组合组成。微小气泡最有效的实现技术之一是将其用作具有激活超声波潜力的药物载体(美国);这使得该药物可以由美国发布。微泡通常被设计用于在药物或物质到达某个关注区域之前保存和保护它们,最后,超声用于分解微泡,引发生物活性药物的特定位点泄漏/释放。它们对多种常见疾病具有出色的治疗潜力。在本文中,我们讨论了微泡及其在治疗某些常见疾病中的优势医学用途,包括帕金森病、阿尔茨海默病、心血管疾病、糖尿病、肾缺陷,最后,它们在治疗各种形式的癌症中的用途以及它们与纳米颗粒的结合。使用微泡技术作为新型载体,预防和根除流行疾病的能力增强了有效护理的前景,从而改善患者的福祉和预期寿命。
更新日期:2021-06-21
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