ABSTRACT

Introduction

Oral squamous cell carcinoma (OSCC) and oral potentially malignant disorders (OPMD) are a significant health burden globally. Smoking, alcohol, and betel quid are the main risk factors. Lack of screening methods has been highlighted as a significant challenge in management. Salivary biomarkers are proposed as noninvasive diagnostic tools. The aim of this systematic review was to study salivary biomarkers reported in OSCC and OPMD. Specific objectives were to select a salivary biomarker panel suitable for early detection of OSCC and OPMD and to assess relationships between salivary biomarkers and risk factors.

Methods

Electronic literature search was conducted in academic databases (Scopus, Medline, Embase and Web of Science) without any restrictions. Following calibration, two blinded reviewers screened the studies and extracted data. A risk of bias assessment was conducted using Newcastle Ottawa scale. 295 studies were included with descriptive data analysis.

Expert opinion

A salivary biomarker panel including Interleukin (IL) 1β, IL6, and IL8 was selected for OSCC and OPMD. Reported relationships between salivary biomarkers and risk factors are discussed and research gaps are highlighted. Future research should be directed to assess potential salivary biomarkers and their relationships to risk factors in order to understand the biomarker’s role in disease initiation.

中文翻译：

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口腔癌和口腔潜在恶性疾病的诊断唾液生物标志物及其与危险因素的关系——系统评价

摘要

介绍

口腔鳞状细胞癌 (OSCC) 和口腔潜在恶性疾病 (OPMD) 是全球重大的健康负担。吸烟、酗酒和吃槟榔是主要的危险因素。缺乏筛选方法已被强调为管理中的一项重大挑战。唾液生物标志物被提议作为非侵入性诊断工具。本系统评价的目的是研究 OSCC 和 OPMD 报告的唾液生物标志物。具体目标是选择适合早期检测 OSCC 和 OPMD 的唾液生物标志物组，并评估唾液生物标志物与风险因素之间的关系。

方法

在学术数据库（Scopus、Medline、Embase 和 Web of Science）中进行电子文献检索，没有任何限制。校准后，两名不知情的评审员筛选研究并提取数据。使用纽卡斯尔渥太华量表进行偏倚风险评估。描述性数据分析纳入了 295 项研究。

专家意见

为 OSCC 和 OPMD 选择了包括白细胞介素 (IL) 1β、IL6 和 IL8 的唾液生物标志物组。讨论了唾液生物标志物与风险因素之间的报告关系，并强调了研究空白。未来的研究应针对评估潜在的唾液生物标志物及其与风险因素的关系，以了解生物标志物在疾病发生中的作用。