Intestinal organoids have been used to model development of the crypt–villus axis and uncover signalling pathways that govern the stem-cell niche and induce differentiation. Two studies now take advantage of intestinal organoids to measure the mechanical forces that drive morphogenesis of the crypt and fate specification of its resident cells.

中文翻译：

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隐窝形态发生的机制

肠道类器官已被用于模拟隐窝-绒毛轴的发育，并揭示控制干细胞生态位和诱导分化的信号通路。现在有两项研究利用肠道类器官来测量驱动隐窝形态发生及其常驻细胞命运规范的机械力。