Clinical and neuroimaging findings in MOGAD–MRI and OCT,Clinical & Experimental Immunology

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Clinical and neuroimaging findings in MOGAD–MRI and OCT
Clinical & Experimental Immunology ( IF 3.4 ) Pub Date : 2021-06-21 , DOI: 10.1111/cei.13641
Frederik Bartels _{1,

2} , Angelo Lu _{3,

4} , Frederike Cosima Oertel _{3,

4} , Carsten Finke _{1,

2} , Friedemann Paul _{1,

3,

4} , Claudia Chien _{3,

4,

5}

Affiliation

Myelin oligodendrocyte glycoprotein antibody-associated disorders (MOGAD) are rare in both children and adults, and have been recently suggested to be an autoimmune neuroinflammatory group of disorders that are different from aquaporin-4 autoantibody-associated neuromyelitis optica spectrum disorder and from classic multiple sclerosis. In-vivo imaging of the MOGAD patient central nervous system has shown some distinguishing features when evaluating magnetic resonance imaging of the brain, spinal cord and optic nerves, as well as retinal imaging using optical coherence tomography. In this review, we discuss key clinical and neuroimaging characteristics of paediatric and adult MOGAD. We describe how these imaging techniques may be used to study this group of disorders and discuss how image analysis methods have led to recent insights for consideration in future studies.

中文翻译：

MOGAD-MRI 和 OCT 的临床和神经影像学结果

髓磷脂少突胶质细胞糖蛋白抗体相关疾病 (MOGAD) 在儿童和成人中都很罕见，最近被认为是一组自身免疫性神经炎症疾病，不同于水通道蛋白 4 自身抗体相关视神经脊髓炎谱系疾病和经典的多发性硬化症。在评估大脑、脊髓和视神经的磁共振成像以及使用光学相干断层扫描的视网膜成像时，MOGAD 患者中枢神经系统的体内成像显示出一些显着特征。在这篇综述中，我们讨论了儿童和成人 MOGAD 的关键临床和神经影像学特征。我们描述了如何使用这些成像技术来研究这组疾病，并讨论图像分析方法如何得出最新的见解，以供未来研究考虑。

更新日期：2021-06-21

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