Silver nanomaterials (AgNMs) ubiquitously known for their biological applications are studied here in terms of their shape-dependent antibacterial and anti-biofilm effect. Chemically synthesized nano-cubes (AgNCs) with size range around 150–200 nm were compared for their biological activity with commercial nano-sphere (AgNS) of comparable size (~160 nm). The antibacterial activity against both Escherichia coli and Staphylococcus aureus showed higher activity for nano-cubes compared with nano-spheres.The synergistic role of AgNMs with antibiotic ampicillin was also found promising. A four times enhancement and an increase of nearly 25% of antibiotic activity at 0.0625 mg ml^–1 concentration was found with 0.05 mg ml^–1 of AgNCs in agar and broth media, respectively. Anti-biofilm effect towards E. coli and S. aureus was also evaluated. AgNCs showed equal importance in biofilm disruption with 20% inhibition activity, which was yet again found better in-comparison with AgNSs. The study shows that AgNCs with distinct faces and edges could show efficient anti-bacterial effect and so such intelligently designed material could pave path for imminent medical challenges.

银纳米材料 (AgNMs) 因其生物应用而广为人知，这里研究了它们的形状依赖性抗菌和抗生物膜效应。将尺寸范围约为 150-200 nm 的化学合成纳米立方体 (AgNC) 的生物活性与具有可比尺寸 (~160 nm) 的商业纳米球 (AgNS) 进行比较。与纳米球相比，纳米立方体对大肠杆菌和金黄色葡萄球菌的抗菌活性显示出更高的活性。AgNMs 与抗生素氨苄青霉素的协同作用也被发现是有希望的。0.05 mg ml ^–1浓度为0.0625 mg ml ^{–1 时}，抗生素活性提高了四倍，增加了近 25%分别在琼脂和肉汤培养基中的 AgNCs。对大肠杆菌和S 的抗生物膜作用。还评估了金黄色葡萄球菌。AgNCs 在生物膜破坏中表现出同样重要的 20% 抑制活性，再次发现与 AgNSs 相比更好。该研究表明，具有不同面和边缘的 AgNCs 可以显示出有效的抗菌作用，因此这种智能设计的材料可以为即将到来的医学挑战铺平道路。