The use of effective disinfectants is a key method of controlling the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Hypochlorous acid water (HAW) has a broad spectrum of virucidal activities. We previously reported that acidic electrolyzed water, one of the HAW products, had potent SARS-CoV-2-inactivating activity and showed promise as a disinfectant. However, different manufacturing methods have produced several HAW products with various pH values. Here, we compared the SARS-CoV-2-inactivating activities of various HAW products. At sufficiently high volume and residual chlorine concentration (RCC), the HAW products inactivated SARS-CoV-2 efficiently regardless of pH or manufacturing method. However, although HAW products at pH 5.0–6.4 maintained high RCC and sustained virucidal activity for 21 days, the RCC rapidly decreased in HAW products at pH ≤ 3.0. Our results may guide in choosing appropriate HAW products for different usage situations.

使用有效的消毒剂是控制严重急性呼吸系统综合症冠状病毒 2 (SARS-CoV-2) 传播的关键方法。次氯酸水 (HAW) 具有广泛的杀病毒活性。我们之前曾报道过，HAW 产品之一的酸性电解水具有有效的 SARS-CoV-2 灭活活性，并显示出作为消毒剂的前景。然而，不同的制造方法已经生产出几种具有不同 pH 值的 HAW 产品。在这里，我们比较了各种 HAW 产品的 SARS-CoV-2 灭活活性。在足够高的体积和余氯浓度 (RCC) 下，HAW 产品可以有效地灭活 SARS-CoV-2，无论 pH 值或制造方法如何。然而，尽管 HAW 产品在 pH 5.0-6.4 保持高 RCC 并持续 21 天的杀病毒活性，在 pH ≤ 3.0 时，HAW 产品的 RCC 迅速下降。我们的结果可以指导为不同的使用情况选择合适的 HAW 产品。