Hospital effluent (HE) is one of the most important sources of pharmaceuticals released into the environment. This kind of pollution is a recognized problem for both human health and aquatic life. Consequently, in the present study, we assessed the effects of untreated hospital effluent on mice via biochemical and histopathological determinations. Female mice were given free access to water bottles containing untreated HE at different dilutions for 21 days. Then clinical biochemistry and histopathology evaluation were conducted. Serum biochemistry analysis showed the presence of significant increase in cholesterol, triglycerides, glycaemia and total bilirubin. However, phosphatase alkaline and urea activities have been significantly decreased compared to the control group. No significant variation was observed for the rest of the studied parameters (high-density lipoproteins; low-density lipoproteins and uric acid). Additionally, multiple alterations, including cellular necrosis, leucocyte infiltration and congestion, were observed in different tissues of mice exposed to the tested HE.

医院污水 (HE) 是药物释放到环境中的最重要来源之一。这种污染是人类健康和水生生物公认的问题。因此，在本研究中，我们通过生化和组织病理学测定评估了未经处理的医院污水对小鼠的影响。在 21 天内，雌性小鼠可以自由使用含有不同稀释度未处理 HE 的水瓶。然后进行临床生化和组织病理学评估。血清生化分析显示胆固醇、甘油三酯、血糖和总胆红素显着增加。然而，与对照组相比，磷酸酶碱性和尿素活性已显着降低。其余研究参数（高密度脂蛋白；低密度脂蛋白和尿酸）未观察到显着变化。此外，在暴露于测试 HE 的小鼠的不同组织中观察到多种改变，包括细胞坏死、白细胞浸润和充血。