The neural control of muscular activity during a voluntary movement implies a continuous updating of a mix of afferent and efferent information. Corticomuscular coherence (CMC) is a powerful tool to explore the interactions between the motor cortex and the muscles involved in movement realization. The comparison of the temporal dynamics of CMC between healthy subjects and post-stroke patients could provide new insights into the question of how agonist and antagonist muscles are controlled related to motor performance during active voluntary movements. We recorded scalp electroencephalography activity, electromyography signals from agonist and antagonist muscles, and upper limb kinematics in eight healthy subjects and seventeen chronic post-stroke patients during twenty repeated voluntary elbow extensions and explored whether the modulation of the temporal dynamics of CMC could contribute to motor function impairment. Concomitantly with the alteration of elbow extension kinematics in post-stroke patients, dynamic CMC analysis showed a continuous CMC in both agonist and antagonist muscles during movement and highlighted that instantaneous CMC in antagonist muscles was higher for post-stroke patients compared to controls during the acceleration phase of elbow extension movement. In relation to motor control theories, our findings suggest that CMC could be involved in the online control of voluntary movement through the continuous integration of sensorimotor information. Moreover, specific alterations of CMC in antagonist muscles could reflect central command alterations of the selectivity in post-stroke patients.

中文翻译：

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皮质肌肉连贯性的时间动态反映了卒中后患者神经运动控制中枢机制的改变

随意运动期间肌肉活动的神经控制意味着传入和传出信息混合的持续更新。皮质肌肉连贯性 (CMC) 是探索运动皮层和参与运动实现的肌肉之间相互作用的有力工具。健康受试者和中风后患者之间 CMC 时间动态的比较可以为主动随意运动期间如何控制主动肌和拮抗肌与运动表现相关的问题提供新的见解。我们记录了头皮脑电图活动，来自主动肌和拮抗肌的肌电信号，和 8 名健康受试者和 17 名慢性中风后患者在 20 次重复自愿肘部伸展期间的上肢运动学和上肢运动学，并探讨了 CMC 时间动态的调节是否会导致运动功能障碍。随着中风后患者肘部伸展运动学的改变，动态 CMC 分析显示运动过程中主动肌和拮抗肌的 CMC 连续，并强调与加速期间的对照组相比，中风后患者的拮抗肌中的瞬时 CMC 更高肘部伸展运动阶段。关于运动控制理论，我们的研究结果表明，CMC 可以通过感觉运动信息的持续整合参与随意运动的在线控制。而且，