Electrochemical Installation of CFH2−, CF2H−, CF3−, and Perfluoroalkyl Groups into Small Organic Molecules,The Chemical Record

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Electrochemical Installation of CFH2−, CF2H−, CF3−, and Perfluoroalkyl Groups into Small Organic Molecules
The Chemical Record ( IF 7.0 ) Pub Date : 2021-06-21 , DOI: 10.1002/tcr.202100065
Camila M Kisukuri ₁ , Vitor A Fernandes ₁ , José A C Delgado ₁ , Andreas P Häring ₂ , Márcio W Paixão ₁ , Siegfried R Waldvogel ₂

Affiliation

Electrosynthesis can be considered a powerful and sustainable methodology for the synthesis of small organic molecules. Due to its intrinsic ability to generate highly reactive species under mild conditions by anodic oxidation or cathodic reduction, electrosynthesis is particularly interesting for otherwise challenging transformations. One such challenge is the installation of fluorinated alkyl groups, which has gained significant attention in medicinal chemistry and material science due to their unique physicochemical features. Unsurprisingly, several electrochemical fluoroalkylation methods have been established. In this review, we survey recent developments and established methods in the field of electrochemical mono-, di-, and trifluoromethylation, and perfluoroalkylation of small organic molecules.

中文翻译：

CFH2−、CF2H−、CF3− 和全氟烷基在有机小分子中的电化学安装

电合成可以被认为是合成有机小分子的一种强大且可持续的方法。由于其在温和条件下通过阳极氧化或阴极还原产生高活性物质的固有能力，电合成对于其他具有挑战性的转化特别有趣。其中一个挑战是氟化烷基的安装，由于其独特的物理化学特性，它在药物化学和材料科学中受到了极大的关注。不出所料，已经建立了几种电化学氟烷基化方法。在这篇综述中，我们调查了有机小分子电化学单、二和三氟甲基化以及全氟烷基化领域的最新进展和已建立的方法。

更新日期：2021-06-21

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