Introduction We aimed to investigate the individual and combined effects of age-specific and sex-specific pulse pressure (PP) and brachial-ankle pulse wave velocity (baPWV) on the incidence of new-onset diabetes mellitus. Research design and methods Participants in the Kailuan study cohort who were ≥20 years old, participated in follow-up assessments and underwent baPWV measurements in 2010–2011, 2012–2013, and 2014–2015 were studied. The participants were allocated to four groups according to their PP and baPWV status, each categorized as high or normal, according to age-specific and sex-specific median values. Cox proportional hazards models were used to explore the individual and combined effects of PP and baPWV on the incidence of diabetes mellitus. Results There were 18 619 participants who were followed for 4.27±1.91 years. A total of 877 new cases of diabetes were identified, and the incidence density was 11.03/1000 per year. Using the normal PP and normal baPWV group as the reference group, the multivariable-adjusted HRs and 95% CIs for diabetes mellitus in the high PP and high baPWV groups were 1.08 (0.93 to 1.25) and 1.64 (1.41 to 1.90), respectively. Compared with the normal PP/baPWV group, the HR and 95% CI for diabetes in the normal PP/high baPWV, the high PP/normal baPWV, and high PP/baPWV groups were 1.66 (1.35 to 2.05), 1.09 (0.86 to 1.37), and 1.74 (1.43 to 2.13), respectively. Conclusions High baPWV was independently associated with a higher risk of diabetes mellitus, and individuals with both high baPWV and high PP were at a still higher risk of diabetes mellitus. No data are available. Proposals for collaborative research can be submitted to Wu(drwusl@163.com)

中文翻译：

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年龄特异性和性别特异性脉压和臂踝脉搏波速度对新发糖尿病风险的个体和综合贡献

引言 我们旨在研究年龄特异性和性别特异性脉压 (PP) 和臂踝脉搏波速度 (baPWV) 对新发糖尿病发病率的个体和综合影响。研究设计和方法 开滦研究队列中年龄≥20 岁、参与随访评估并在 2010-2011、2012-2013 和 2014-2015 年进行 baPWV 测量的参与者进行了研究。参与者根据他们的 PP 和 baPWV 状态被分配到四组，每组根据年龄特定和性别特定的中值分为高或正常。Cox 比例风险模型用于探讨 PP 和 baPWV 对糖尿病发病率的个体和组合影响。结果共有18 619名参与者被随访4.27±1.91年。共发现糖尿病新发病例877例，发病密度为11.03/1000/年。使用正常 PP 和正常 baPWV 组作为参考组，高 PP 和高 baPWV 组糖尿病的多变量调整 HR 和 95% CI 分别为 1.08（0.93 至 1.25）和 1.64（1.41 至 1.90）。与正常 PP/baPWV 组相比，正常 PP/高 baPWV、高 PP/正常 baPWV 和高 PP/baPWV 组的糖尿病 HR 和 95% CI 分别为 1.66（1.35 至 2.05）、1.09（0.86 至1.37）和 1.74（1.43 到 2.13）。结论 高 baPWV 与较高的糖尿病风险独立相关，同时具有高 baPWV 和高 PP 的个体患糖尿病的风险更高。没有可用数据。