Human iPSC-derived neural precursor cells differentiate into multiple cell types to delay disease progression following transplantation into YAC128 Huntington's disease mouse model,Cell Proliferation

当前位置： X-MOL 学术 › Cell Prolif. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Human iPSC-derived neural precursor cells differentiate into multiple cell types to delay disease progression following transplantation into YAC128 Huntington's disease mouse model
Cell Proliferation ( IF 5.9 ) Pub Date : 2021-06-21 , DOI: 10.1111/cpr.13082
Hyun Jung Park ₁ , Juhyun Jeon ₁ , Jiwoo Choi ₁ , Ji Yeon Kim ₁ , Hyun Sook Kim ₂ , Ji Young Huh ₃ , Steven A Goldman _{4,

5} , Jihwan Song _{1,

6}

Affiliation

To investigate whether human HLA-homozygous induced pluripotent stem cell (iPSC)-derived neural precursor cells (iPSC-NPCs) can provide functional benefits in Huntington’s disease (HD), we transplanted them into the YAC128 transgenic HD mouse model.

中文翻译：

人类 iPSC 衍生的神经前体细胞分化成多种细胞类型以延缓移植到 YAC128 亨廷顿病小鼠模型后的疾病进展

为了研究人类 HLA 纯合诱导多能干细胞 (iPSC) 衍生的神经前体细胞 (iPSC-NPC) 是否可以为亨廷顿病 (HD) 提供功能益处，我们将它们移植到 YAC128 转基因 HD 小鼠模型中。

更新日期：2021-08-09

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11