Abstract

Objective

We investigate the relationship between sarcopenia components and depression in geriatric outpatients, considering the effects of potential confounding factors.

Methods

Adults ≥60 years of age were selected from outpatient clinics. Muscle strength was assessed using handgrip strength (HGS) measured using a hydraulic hand dynamometer and chair stand test (CSST). Physical performance was evaluated by usual gait speed (UGS), nutritional status, and frailty were screened by mini-nutritional assessment (MNA) questionnaire and FRAIL scale. Depression was diagnosed through a psychiatric interview and the administration of the Geriatric Depression Scale (GDS).

Results

Participants with depression were similar to participants without depression regarding age (p = .055), education (p = .095), frailty (p = .857), and HGS scores (p = .053). The group with depression had longer CSST duration (p = .023), slower UGS (p = .027), and more malnutrition (p = .001). Multivariate regression analysis revealed that only the malnutrition was independently associated factor with depression after adjusting for confounding factors.

Conclusions

Depression is associated with malnutrition and some components of sarcopenia in geriatric outpatients. Our results revealed that sarcopenia might be associated with depression through malnutrition. If malnutrition lasts for a long time, sarcopenia may become evident in the later stages of depression.

中文翻译：

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阐明老年门诊患者肌肉减少症与抑郁症的关系

摘要

客观的

考虑到潜在混杂因素的影响，我们研究了老年门诊患者的肌肉减少症成分与抑郁症之间的关系。

方法

从门诊选择≥60岁的成年人。使用液压手测力计和椅架测试 (CSST) 测量的握力 (HGS) 评估肌肉力量。通过常规步态速度（UGS）评估身体表现，通过迷你营养评估（MNA）问卷和FRAIL量表筛选营养状况和虚弱程度。通过精神病学访谈和老年抑郁量表（GDS）的管理诊断出抑郁症。

结果

患有抑郁症的参与者在年龄 ( p  = .055)、教育程度 ( p = .095)  、虚弱 ( p  = .857) 和 HGS 评分 ( p = .053)方面与没有抑郁症的参与者相似 。抑郁症组的 CSST 持续时间更长（ p = .023），  UGS 更慢（p  = .027），营养不良更多（p  = .001）。多元回归分析显示，在调整混杂因素后，只有营养不良是与抑郁症独立相关的因素。

结论

抑郁症与老年门诊患者的营养不良和肌肉减少症的某些成分有关。我们的研究结果表明，肌肉减少症可能与营养不良导致的抑郁症有关。如果营养不良持续很长时间，则在抑郁症的后期可能会出现肌肉减少症。