Abstract

Tartrazine is used in the pharmaceutical, cosmetic, and food industries worldwide, despite its many toxic effects. The therapeutic effects of crocin (50 mg/kg/day) against tartrazine-induced (500 mg/kg/day) oxidative damage in ileum and colon tissues in rats have been investigated. Malondialdehyde and total oxidant status levels elevated by tartrazine within the ileum and colon tissues were reduced with crocin treatment, while tartrazine decreased antioxidative parameters (glutathione, total antioxidant status, superoxide dismutase, and catalase) were reverted. Tartrazine-induced histopathological changes of ileum and colon tissues were ameliorated following crocin treatment. In conclusion, Tartrazine consumption elicited tissue injury via lipid peroxidation, and crocin ameliorated oxidative injury by its antioxidant and free radical scavenger properties.

摘要

尽管柠檬黄具有许多毒性作用，但它仍被用于全球的制药、化妆品和食品行业。已经研究了藏红花素（50 毫克/千克/天）对大鼠回肠和结肠组织中柠檬黄诱导的（500 毫克/千克/天）氧化损伤的治疗效果。用藏红花素处理后，回肠和结肠组织中由柠檬黄升高的丙二醛和总氧化状态水平降低，而柠檬黄降低的抗氧化参数（谷胱甘肽、总抗氧化状态、超氧化物歧化酶和过氧化氢酶）得到恢复。酒石黄诱导的回肠和结肠组织的组织病理学变化在藏红花素治疗后得到改善。总之，柠檬黄消耗通过脂质过氧化引起组织损伤，