This paper reports a computational modelling study of a mixing tank for bioprocess applications. A dual impeller mixer containing several probes is used with a mixing speed of 400 rpm. The single-phase transient model is validated against experimental measurements using torque and velocity profiles as the validation variables. A complete workflow is illustrated that addresses all the relevant steps in the modelling of mixing. Many assumptions that are commonly made are explored and their importance is demonstrated. The necessity of including the probes in the computational domain is illustrated. The grid and time-step size are examined, and the relationship between the two is explained. Two turbulence models for RANS equation closure are compared, and the efficacy of the appropriate solution methodology for each is described. The importance of using the correct near-wall treatment is shown. Overall, this paper presents a standardized framework for the modelling of mixing tanks with turbulent flow.

中文翻译：

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生物过程混合罐的计算建模：开发综合工作流程

本文报告了用于生物工艺应用的混合罐的计算建模研究。使用包含多个探头的双叶轮混合器，混合速度为 400 rpm。单相瞬态模型通过使用扭矩和速度曲线作为验证变量的实验测量进行验证。说明了一个完整的工作流程，解决了混合建模中的所有相关步骤。探索了许多通常做出的假设，并证明了它们的重要性。说明了在计算域中包含探针的必要性。检查网格和时间步长，并解释两者之间的关系。比较了 RANS 方程闭合的两个湍流模型，并描述了每个模型的适当求解方法的功效。显示了使用正确的近壁处理的重要性。总体而言，本文提出了一个标准化框架，用于对湍流混合罐进行建模。