Excess caloric intake and irregular circadian rhythm could severely impair female reproductive, metabolic, and immune function. However, the similarities and differences between their individual and combined effects and mechanisms have not been fully elucidated. Due to limitations and confounding factors in clinical research, we used these two kinds of unhealthy factors to intervene the mice singly or in combination to explore their effects on individuals.

中文翻译：

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高热量饮食和持续光照对雌性生殖、代谢和免疫炎症的影响：不同小鼠模型的比较研究


过多的热量摄入和不规律的昼夜节律可能会严重损害女性的生殖、代谢和免疫功能。然而，它们的个体和组合效应和机制之间的异同尚未完全阐明。由于临床研究的局限性和混杂因素，我们利用这两种不健康因素对小鼠进行单独或联合干预，探讨其对个体的影响。