Ineffective esophageal motility (IEM) is the most common motility disorder. However, little is known about its pathophysiology. Vagal afferent nerves convey esophageal intraluminal bolus information to solitary nucleus, which is likely to be involved with esophageal primary and secondary peristalsis (SP). We hypothesized that altered mucosal sensory afferents underlie the pathogenesis of IEM.

中文翻译：

---

食管动力无效患者的食管黏膜感觉神经和潜在机械感受器

无效食管动力（IEM）是最常见的动力障碍。然而，对其病理生理学知之甚少。迷走神经传入神经将食管腔内推注信息传递给孤立核，这可能与食管原发性和继发性蠕动（SP）有关。我们假设改变的黏膜感觉传入是 IEM 发病机制的基础。