Solution structure of the anticancer p28 peptide in biomimetic medium,Journal of Peptide Science

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Solution structure of the anticancer p28 peptide in biomimetic medium
Journal of Peptide Science ( IF 1.8 ) Pub Date : 2021-06-20 , DOI: 10.1002/psc.3357
Francesca Cantini _{1,

2} , Paola Gianni' ₃ , Philippe Savarin ₄ , Anna Rita Bizzarri ₅ , Marco Sette _{3,

4}

Affiliation

The p28 peptide derived from Pseudomonas aeruginosa azurin shows an anticancer activity after binding to p53 protein and is currently in Phase I of clinical trials. We have studied its structure in water and in a biomimetic media and show that the peptide is unstructured in water but when studied in a biomimetic medium assumes a structure very similar to the one observed in azurin, suggesting a high propensity of this peptide to maintain this secondary structure. Analysis of p28 sequences from different bacterial species indicates conservation of the secondary structure despite amino acid replacement in different positions, suggesting that others, similar peptides could be tested for binding to p53.

中文翻译：

抗癌p28肽在仿生培养基中的溶液结构

来源于绿脓杆菌的p28肽与p53蛋白结合后显示出抗癌活性，目前处于临床I期。我们研究了它在水中和仿生介质中的结构，并表明该肽在水中是非结构化的，但在仿生介质中研究时，其结构与在天青蛋白中观察到的结构非常相似，这表明该肽很容易保持这种结构。二级结构。对来自不同细菌物种的 p28 序列的分析表明，尽管在不同位置进行了氨基酸置换，但二级结构的保守性，表明可以测试其他类似的肽与 p53 的结合。

更新日期：2021-06-20

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