Ac106/107 affects production of infectious progeny BV by regulating transcription of late viral genes and host cell energy metabolism,Pest Management Science

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Ac106/107 affects production of infectious progeny BV by regulating transcription of late viral genes and host cell energy metabolism
Pest Management Science ( IF 3.8 ) Pub Date : 2021-06-20 , DOI: 10.1002/ps.6520
Jingli Wang ₁ , Ke Li ₂ , Yuejun Fu ₁

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AcMNPV is a model organism of baculovirus, and Spodoptera frugiperda is one of its hosts. Disclosing the role of ac106/107 in AcMNPV infecting Spodoptera frugiperda 9 (Sf9) cells is of great significance for modifying AcMNPV as a microbial insecticide. This work constructed recombinant baculovirus that knocking out, repairment and overexpression of ac106/107 and explored the effects of Ac106/107 on the proliferation of progeny viruses. Moreover, the potential mechanism and targets of ac106/107 were further revealed.

中文翻译：

Ac106/107 通过调节晚期病毒基因的转录和宿主细胞能量代谢来影响感染性后代 BV 的产生

AcMNPV是杆状病毒的模式生物，草地贪夜蛾是其宿主之一。披露的作用ac106 / 107在AcMNPV病毒感染草地夜蛾9（的Sf9）细胞具有重要的意义，用于修改AcMNPV的作为微生物杀虫剂。本工作构建了敲除、修复和过表达ac106/107的重组杆状病毒，并探讨了Ac106/107对子代病毒增殖的影响。此外，进一步揭示了ac106/107的潜在机制和靶点。

更新日期：2021-06-20

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