This study demonstrated the effect of positional isomerism of benzoic acid derivatives against E. coli ATCC 700728 with the serotype O157. The addition of hydroxyl and methoxyl substituents weakened the effect of acids against E. coli with respect to benzoic acid (except 2-hydroxybenzoic). The connection of the hydroxyl group at the second carbon atom in the benzoic ring reduced the time needed to kill bacterial cells. Phenolic acids with methoxyl substitutes limited the biofilm formation by E. coli to a greater extent than hydroxyl derivatives. The most significant influence on the antibacterial activity of phenolic acids has the type of substituent attached to the benzoic ring, their number, and finally the number of carbon atoms at which the functional group is located.

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苯甲酸衍生物的位置异构对大肠杆菌抗菌活性的影响


本研究证明了苯甲酸衍生物的位置异构对血清型 O157 大肠杆菌 ATCC 700728 的影响。相对于苯甲酸（2-羟基苯甲酸除外），羟基和甲氧基取代基的添加削弱了酸对大肠杆菌的作用。苯甲环第二个碳原子上的羟基连接减少了杀死细菌细胞所需的时间。与羟基衍生物相比，具有甲氧基取代物的酚酸在更大程度上限制了大肠杆菌的生物膜形成。对酚酸抗菌活性最重要的影响是苯甲环上取代基的类型、取代基的数量，以及官能团所在的碳原子数。