ASSESSMENT OF PATIENT’S RADIATION EXPOSURES RESULTED FROM PET/CT 18F-FCH AND 68GA-PSMA PROCEDURES,Radiation Protection Dosimetry

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ASSESSMENT OF PATIENT’S RADIATION EXPOSURES RESULTED FROM PET/CT 18F-FCH AND 68GA-PSMA PROCEDURES
Radiation Protection Dosimetry ( IF 0.8 ) Pub Date : 2021-05-10 , DOI: 10.1093/rpd/ncab077
H Salah _{1,

2} , H I Al-Mohammed ₃ , F H Mayhoub ₄ , A Sulieman ₅ , M Alkhorayef _{6,

7} , Fouad A Abolaban ₈ , Mayeen Uddin Khandaker ₉ , D A Bradley _{7,

9}

Affiliation

INAYA Medical Collage, Nuclear Medicine Department, P.O. Box 271880, Riyadh 11352, Saudi Arabia.
Basic Science Department, College of Medical Radiologic Science, Sudan University of Science and Technology, P.O.Box 1908, Khartoum 11111, Sudan.
Department of Radiological Sciences, College of Health and Rehabilitation Sciences, Princess Nourah Bint Abdulrahman University, P.O. Box 84428, Riyadh 11671 Saudi Arabia.
Department of Biomedical Physics, King Faisal Specialist Hospital & Research Centre, P.O. Box 3354, Riyadh 11211, Saudi Arabia.
Prince Sattam Bin Abdulaziz University, College of Applied Medical Sciences, Radiology and Medical Imaging Department, P.O.Box 422, Alkharj 11942, Saudi Arabia.
Department of Radiological Sciences, College of Applied Medical Sciences, King Saud University, P.O.Box 10219, Riyadh 11433, Saudi Arabia.
Centre for Nuclear and Radiation Physics, Department of Physics, University of Surrey, Guildford GU2 7XH, UK.
Nuclear Engineering Department, Faculty of Engineering, King Abdulaziz University, P. O. Box 80221, Jeddah 21589, Saudi Arabia.
Centre for Biomedical Physics, School of Healthcare and Medical Sciences, Sunway University, 47500 46150 PJ, Bandar, No. 5, Jalan Universiti, Sunway, Selangor Darul Ehsan, Malaysia.

This study has sought to evaluate patient exposures during the course of particular diagnostic positron emission tomography and computed tomography (PET/CT) techniques. A total of 73 patients were examined using two types of radiopharmaceutical: 18F-fluorocholine (FCH, 48 patients) and 68Ga-prostate-specific membrane antigen (PSMA, 25 patients). The mean and range of administered activity (AA) in MBq, and effective dose (mSv) for FCH were 314.4 ± 61.6 (462.5–216.8) and 5.9 ± 1.2 (8.8–4.11), respectively. Quoted in the same set of units, the mean and range of AA and effective dose for 68Ga-PSMA were 179.3 ± 92.3 (603.1–115.1) and 17.9 ± 9.2 (60.3–11.5). Patient effective doses from 18F-FCH being a factor of two greater than the dose resulting from 68Ga-PSMA PET/CT procedures. CT accounts for some 84 and 23% for 18F-FCH and 68Ga-PSMA procedures, accordingly CT acquisition parameter optimization is recommended. Patient doses have been found to be slightly greater than previous studies.

中文翻译：

PET/CT 18F-FCH 和 68GA-PSMA 程序导致的患者辐射暴露评估

本研究试图评估在特定诊断正电子发射断层扫描和计算机断层扫描 (PET/CT) 技术过程中患者的暴露情况。使用两种类型的放射性药物检查了总共 73 名患者：18F-氟胆碱（FCH，48 名患者）和 68Ga-前列腺特异性膜抗原（PSMA，25 名患者）。MBq 中给药活性 (AA) 的平均值和范围以及 FCH 的有效剂量 (mSv) 分别为 314.4 ± 61.6 (462.5–216.8) 和 5.9 ± 1.2 (8.8–4.11)。引用同一组单位，AA 的平均值和范围以及 68Ga-PSMA 的有效剂量分别为 179.3 ± 92.3 (603.1–115.1) 和 17.9 ± 9.2 (60.3–11.5)。来自 18F-FCH 的患者有效剂量是 68Ga-PSMA PET/CT 程序产生的剂量的两倍。CT 占 18F-FCH 和 68Ga-PSMA 程序的 84% 和 23%，因此建议对 CT 采集参数进行优化。已发现患者剂量略高于以前的研究。

更新日期：2021-05-10

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