Antimicrobial peptides (AMPs), a part of the natural defence against pathogens, have been considered as alternative antibiotics to combat the increase of antimicrobial resistance (AMR). Given the advanced development of fluorescent probes, extensive research has been focussed on understanding the physiological processes of the interaction between AMPs and bacteria. To better guide the choice of suitable fluorescent reporters for the mechanism study of AMPs, in this review, we summarise a toolbox of commonly used fluorescent reporters for AMP studies, including intrinsic fluorescent reporters, conventional fluorophores, and recently developed aggregation-induced emission (AIE) fluorogens.

抗菌肽 (AMP) 是抵御病原体的自然防御的一部分，已被认为是对抗抗菌素耐药性 (AMR) 增加的替代抗生素。鉴于荧光探针的先进发展，广泛的研究集中在了解 AMP 与细菌之间相互作用的生理过程。为了更好地指导选择适合 AMP 机制研究的荧光报告基因，在这篇综述中，我们总结了一个用于 AMP 研究的常用荧光报告基因工具箱，包括固有荧光报告基因、常规荧光团和最近开发的聚集诱导发射 (AIE) ) 荧光素。