Co-infection with HIV/HPV and bio-behavioral risk factors (e.g., immunodeficiency, un-protected sex) increase likelihood for developing anal and other HPV-associated cancers among people living with HIV/AIDS (PLWHA). We explored knowledge, attitudes, and health communication regarding HPV-associated anal cancers among HIV/AIDS service organization (ASO) employees/volunteers delivering non-clinical services to PLWHA. Participants (n=59) were recruited from six ASOs located in the South United States Census region and completed a 118-item self-administered survey. For current analyses, outcome measures were knowledge, attitudes, and health communication regarding anal cancer. Descriptive statistics assessed outcome measures which were subsequently dichotomized into binary variables (i.e., high/favorable or low/unfavorable). Fisher’s exact test examined associations between outcome measures and ASO employees/volunteers’ sex/sexual orientation (i.e., heterosexual female, heterosexual male, LGBTI female, LGBTI male). Mean age for ASO employees/volunteers was 45.5 years (±13.5 SD). Participants were heterosexual females (45.7%), LGBTI males (27.3%), heterosexual males (13.5%), and LGBTI females (13.5%). Almost half (44.8%) had not heard about anal Pap screening and 39.0% did not think HPV can cause anal cancer. Overall, 73.9% had low knowledge scores. Participants (47.4%) were unsure or believed HPV vaccinations were non-protective against anal cancer while 94.9% had favorable health communication behaviors. Knowledge regarding anal cancer being linked to HPV (p=0.006) and health information seeking on anal cancer (p=0.000) were statistically significantly different by sex/sexual orientation. Fostering increased knowledge, favorable attitudes, and improved health communication behaviors among ASO employees/volunteers could facilitate dissemination and promotion of anal cancer prevention strategies (anal Pap screenings, HPV vaccinations) among PLWHA.

HIV/HPV 合并感染和生物行为危险因素（例如免疫缺陷、无保护性行为）会增加 HIV/AIDS 感染者 (PLWHA) 患肛门癌和其他 HPV 相关癌症的可能性。我们探讨了向 PLWHA 提供非临床服务的 HIV/AIDS 服务组织 (ASO) 员工/志愿者中有关 HPV 相关肛门癌的知识、态度和健康沟通。参与者 (n=59) 是从位于美国南部人口普查地区的 6 个 ASO 中招募的，并完成了一项包含 118 项的自填调查。对于当前的分析，结果指标是关于肛门癌的知识、态度和健康沟通。描述性统计评估了结果测量，随后将其分为二元变量（即高/有利或低/不利）。 Fisher 精确检验检验了结果测量与 ASO 员工/志愿者的性别/性取向（即异性恋女性、异性恋男性、LGBTI 女性、LGBTI 男性）之间的关联。 ASO 员工/志愿者的平均年龄为 45.5 岁 (±13.5 SD)。参与者包括异性恋女性（45.7%）、LGBTI 男性（27.3%）、异性恋男性（13.5%）和 LGBTI 女性（13.5%）。近一半 (44.8%) 没有听说过肛门巴氏筛查，39.0% 不认为 HPV 会导致肛门癌。总体而言，73.9% 的人知识得分较低。参与者 (47.4%) 不确定或认为 HPV 疫苗接种对预防肛门癌没有保护作用，而 94.9% 的参与者有良好的健康沟通行为。关于肛门癌与 HPV 相关的知识（ p =0.006）以及肛门癌健康信息查询（ p =0.000）在性别/性取向上有统计学上的显着差异。 提高 ASO 员工/志愿者的知识水平、良好态度和改善健康沟通行为，可以促进在 PLWHA 中传播和推广肛门癌预防策略（肛门巴氏筛查、HPV 疫苗接种）。