Moving towards safe and sustainable innovations is an international policy ambition. In the on-hand manuscript, a concept combining safe by design and sustainability was implemented through the integration of human and environmental risk assessment, life cycle assessment as well as an assessment of the economic viability. The result is a nested and iterative process in form of a decision tree that integrates these three elements in order to achieve sustainable, safe and competitive materials, products or services. This approach, embedded into the stage-gate-model for safe by design, allows to reduce the uncertainty related to the assessment of risks and impacts by improving the quality of the data collected along each stage. In the second part of the manuscript, the application is shown for a case study dealing with the application of nanoparticles for Li-Ion batteries. One of the general conclusions out of this case study is that data gaps are a key aspect in view of the reliability of the results.

迈向安全和可持续的创新是一项国际政策目标。在手稿中，通过整合人类和环境风险评估、生命周期评估以及经济可行性评估，实现了设计安全和可持续性相结合的概念。结果是一个以决策树形式出现的嵌套和迭代过程，将这三个要素整合在一起，以实现可持续、安全和有竞争力的材料、产品或服务。这种方法嵌入到设计安全的阶段门模型中，可以通过提高每个阶段收集的数据的质量来减少与风险和影响评估相关的不确定性。在手稿的第二部分，该应用程序展示了一个案例研究，该案例研究涉及纳米粒子在锂离子电池中的应用。本案例研究得出的一般性结论之一是，考虑到结果的可靠性，数据差距是一个关键方面。