当前位置：
X-MOL 学术
›
Can. J. Chem. Eng.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Ionic gelation of chitosan with sodium tripolyphosphate using a novel combined nebulizer and falling film system
The Canadian Journal of Chemical Engineering ( IF 1.6 ) Pub Date : 2021-06-18 , DOI: 10.1002/cjce.24234 Yeganeh Poureghbal 1 , Masoud Rahimi 1 , Mona Akbari 2
The Canadian Journal of Chemical Engineering ( IF 1.6 ) Pub Date : 2021-06-18 , DOI: 10.1002/cjce.24234 Yeganeh Poureghbal 1 , Masoud Rahimi 1 , Mona Akbari 2
Affiliation
|
Nanoparticle technology has made an essential contribution to the pharmaceutical industry and has received considerable attention in comparison with the other domains. In the present study, ionic gelation via a novel combined system of nebulizer and falling film (IG-NFF) has been proposed. The purpose of the design of this system is to increase the contact surface between the chitosan and sodium tripolyphosphate (STPP) for the preparation of monodisperse and spherical chitosan nanoparticles, because in both nebulizer and falling film systems, the surface-to-volume ratio of liquid increases. The formation of these nanoparticles is based on ionic interactions between the negatively charged phosphate groups in the STPP and positively charged amine groups on the chitosan. In this research, the effects of chitosan concentration, STPP concentration, the distance of the nebulizer from the inclined plate, gas to liquid flow rate ratio, and the initial chitosan solution pH on the z-average size, polydispersity index (PDI), and morphology of nanoparticles formed by IG-NFF were studied. The results showed that the IG-NFF process has the ability to produce spherical particles with highly uniform sizes. The mean size of obtained chitosan nanoparticles was in the range of 80–320 nm, and the PDI value ranged from 0.08–0.30.
中文翻译：
新型组合雾化器和降膜系统对壳聚糖与三聚磷酸钠的离子凝胶化
纳米粒子技术为制药行业做出了重要贡献，与其他领域相比，它受到了相当大的关注。在本研究中，已经提出了通过喷雾器和降膜（IG-NFF）的新型组合系统进行离子凝胶化。该系统设计的目的是增加壳聚糖和三聚磷酸钠 (STPP) 之间的接触表面，以制备单分散和球形壳聚糖纳米颗粒，因为在雾化器和降膜系统中，表面与体积比液体增加。这些纳米粒子的形成是基于 STPP 中带负电荷的磷酸基团和壳聚糖上带正电荷的胺基团之间的离子相互作用。在本研究中，壳聚糖浓度、STPP 浓度、研究了雾化器与斜板的距离、气液流速比、初始壳聚糖溶液pH值对IG-NFF形成的纳米粒子z平均尺寸、多分散指数（PDI）和形貌的影响。结果表明，IG-NFF工艺能够生产出尺寸高度均匀的球形颗粒。所得壳聚糖纳米粒子的平均粒径在 80-320 nm 范围内，PDI 值在 0.08-0.30 范围内。
更新日期：2021-06-18
中文翻译：
新型组合雾化器和降膜系统对壳聚糖与三聚磷酸钠的离子凝胶化
纳米粒子技术为制药行业做出了重要贡献，与其他领域相比，它受到了相当大的关注。在本研究中，已经提出了通过喷雾器和降膜（IG-NFF）的新型组合系统进行离子凝胶化。该系统设计的目的是增加壳聚糖和三聚磷酸钠 (STPP) 之间的接触表面，以制备单分散和球形壳聚糖纳米颗粒，因为在雾化器和降膜系统中，表面与体积比液体增加。这些纳米粒子的形成是基于 STPP 中带负电荷的磷酸基团和壳聚糖上带正电荷的胺基团之间的离子相互作用。在本研究中，壳聚糖浓度、STPP 浓度、研究了雾化器与斜板的距离、气液流速比、初始壳聚糖溶液pH值对IG-NFF形成的纳米粒子z平均尺寸、多分散指数（PDI）和形貌的影响。结果表明，IG-NFF工艺能够生产出尺寸高度均匀的球形颗粒。所得壳聚糖纳米粒子的平均粒径在 80-320 nm 范围内，PDI 值在 0.08-0.30 范围内。
京公网安备 11010802027423号